Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 6/20 | 1.00 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.78 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.63 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.50 |
| ▸ | F3 | P13726 | 1/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.47 |
| ▸ | CES2 | O00748 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8639467 | 0.98 | ESR1 (0.96) | ESR1ESR2CYP19A1CYP11B2MAPT | |
| SCHEMBL1948717 | 0.98 | ESR1 (0.96) | ESR1ESR2CYP19A1CYP11B2MAPT | |
| SCHEMBL1948714 | 0.98 | ESR1 (0.96) | ESR1ESR2CYP19A1CYP11B2MAPT | |
| Phenol SCHEMBL18863020 | 0.91 | ESR1 (0.83) | ESR1ESR2CYP19A1CYP11B2TDP1 | |
| SCHEMBL14354218 | 0.91 | ESR1 (0.83) | ESR1ESR2CYP19A1CYP11B2CYP3A4 | |
| SCHEMBL4612465 | 0.88 | ESR1 (0.78) | ESR1ESR2CYP19A1CYP11B2MAPT | |
| SCHEMBL14391815 | 0.86 | ESR1 (0.73) | ESR1ESR2CYP19A1MAPTMEN1 | |
| SCHEMBL55433 | 0.85 | ESR1 (0.74) | ESR1ESR2CYP19A1CYP11B2MAPT | |
| SCHEMBL22046628 | 0.85 | ESR1 (0.72) | ESR1ESR2CYP19A1CYP11B2MAPT | |
| Phosphine SCHEMBL28461311 | 0.83 | ESR1 (0.71) | ESR1ESR2CYP19A1CYP11B2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10590056-B2 | ERR modulators and uses thereof | CITY OF HOPE (US) | 2020-03-17 | — | — | US | disclosed |
| US-20180297923-A1 | ERR MODULATORS AND USES THEREOF | CITY OF HOPE | 2018-10-18 | — | — | US | disclosed |
| US-8119695-B2 | Compounds and methods for treating breast cancer and other diseases | CITY OF HOPE (US) | 2012-02-21 | — | — | US | disclosed |
| US-20090176305-A1 | COMPOUNDS AND METHODS FOR TREATING BREAST CANCER AND OTHER DISEASES | CITY OF HOPE | 2009-07-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180297923-A1 | ERR MODULATORS AND USES THEREOF | ESRRA, ESRRB, ESRRG | ESR1 43/4885ESR2 7/4885CYP19A1 74/4885 |
| US-10590056-B2 | ERR modulators and uses thereof | ESRRA, ESRRB, ESRRG | ESR1 43/4885ESR2 7/4885CYP19A1 74/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.