Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 4/20 | 0.96 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.75 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.61 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.59 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.50 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.48 |
| ▸ | F3 | P13726 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1948714 | 1.00 | ESR1 (0.96) | ESR1ESR2CYP19A1CYP11B2PTGS2 | |
| SCHEMBL1948717 | 1.00 | ESR1 (0.96) | ESR1ESR2CYP19A1CYP11B2PTGS2 | |
| SCHEMBL641985 | 0.98 | ESR1 (1.00) | ESR1ESR2CYP19A1CYP11B2PTGS2 | |
| SCHEMBL14354218 | 0.93 | ESR1 (0.83) | ESR1ESR2CYP19A1CYP11B2PTGS2 | |
| Phenol SCHEMBL18863020 | 0.93 | ESR1 (0.83) | ESR1ESR2CYP19A1CYP11B2PTGS2 | |
| SCHEMBL4612465 | 0.91 | ESR1 (0.78) | ESR1ESR2CYP19A1CYP11B2PTGS2 | |
| SCHEMBL55433 | 0.89 | ESR1 (0.74) | ESR1ESR2CYP19A1CYP11B2PTGS2 | |
| SCHEMBL22046628 | 0.87 | ESR1 (0.72) | ESR1ESR2CYP19A1CYP11B2PTGS2 | |
| Phosphine SCHEMBL28461311 | 0.86 | ESR1 (0.71) | ESR1ESR2CYP19A1CYP11B2PTGS2 | |
| SCHEMBL30366689 | 0.86 | ESR1 (0.71) | ESR1ESR2CYP19A1CYP11B2PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9656947-B2 | Process for creating carbon-carbon bonds using carbonyl compounds | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S) (FR) | 2017-05-23 | — | — | US | disclosed |
| EP-0720597-B1 | TRIARYL-ETHYLENE DERIVATIVES FOR USE IN THERAPY | MERRELL PHARMA INC (US) | 1998-04-29 | — | — | EP | disclosed |
| US-5693674-A | Method of using triaryl-ethylene derivatives in the treatment and prevention of osteoporosis | HOECHST MARION ROUSSEL, INC. (US) | 1997-12-02 | — | — | US | disclosed |
| US-5691384-A | Method of using triaryl-ethylene derivatives in the treatment and prevention of osteoporosis | HOECHST MARION ROUSSEL, INC. (US) | 1997-11-25 | — | — | US | disclosed |
| US-5684004-A | ANTINEOPLASTIC AGENTS, ANTIATHEROSCLEROTIC AGENTS, HYPOCHOLESTEROLEMIC AGENTS | MERRELL PHARMACEUTICALS, INC. (US) | 1997-11-04 | — | — | US | disclosed |
| EP-0794771-A1 | METHOD OF USING TRIARYL-ETHYLENE DERIVATIVES IN THE TREATMENT AND PREVENTION OF OSTEOPOROSIS | HOECHST MARION ROUSSEL, INC. (US) | 1997-09-17 | — | — | EP | disclosed |
| EP-0720597-A1 | TRIARYL-ETHYLENE DERIVATIVES FOR USE IN THERAPY | MERRELL PHARMACEUTICALS INC. (US) | 1996-07-10 | — | — | EP | disclosed |
| US-5525633-A | ANTITUMOR AGENTS, ANTICHOLESTEROL AGENTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1996-06-11 | — | — | US | disclosed |
| WO-1996016646-A1 | METHOD OF USING TRIARYL-ETHYLENE DERIVATIVES IN THE TREATMENT AND PREVENTION OF OSTEOPOROSIS | HOECHST MARION ROUSSEL, INC. (US) | 1996-06-06 | — | — | WO | disclosed |
| WO-1995008528-A1 | TRIARYL-ETHYLENE DERIVATIVES FOR USE IN THERAPY | MERRELL PHARMACEUTICALS INC. (US) | 1995-03-30 | — | — | WO | disclosed |