Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | TBXAS1 | P24557 | 8/20 | 0.45 |
| ▸ | RAB9A | P51151 | 5/20 | 0.45 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | DAO | P14920 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6419876 | 1.00 | HPGDS (0.50) | HPGDSCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL14288480 | 0.84 | HPGDS (0.49) | HPGDSCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL6419827 | 0.81 | L3MBTL1 (0.52) | RAB9ANPC1ALDH1A1LMNAHPGD | |
| SCHEMBL6419828 | 0.81 | L3MBTL1 (0.52) | RAB9ANPC1ALDH1A1LMNAHPGD | |
| SCHEMBL28803436 | 0.80 | HPGDS (0.45) | HPGDSCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL12943229 | 0.79 | HPGDS (0.55) | HPGDSCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL27540190 | 0.79 | HPGDS (0.55) | HPGDSCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL4630812 | 0.78 | MTNR1A (0.48) | CYP1A2CYP2C9CYP2C19TBXAS1ALDH1A1 | |
| SCHEMBL15315140 | 0.76 | CYP19A1 (0.52) | HPGDSCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL124421 | 0.75 | HPGDS (0.59) | HPGDSCYP1A2CYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6972294-B1 | Compounds, their preparation and use | NOVO NORDISK, A/S (DK) | 2005-12-06 | — | — | US | disclosed |
| EP-1171414-A1 | COMPOUNDS, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 2002-01-16 | — | — | EP | disclosed |
| WO-2000063153-A1 | NEW COMPOUNDS, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 2000-10-26 | — | — | WO | disclosed |