Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 3/20 | 0.42 |
| ▸ | DRD2 | P14416 | 3/20 | 0.42 |
| ▸ | HTR7 | P34969 | 3/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 8/20 | 0.36 |
| ▸ | IDO1 | P14902 | 2/20 | 0.36 |
| ▸ | KDM5A | P29375 | 2/20 | 0.36 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.36 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4455923 | 0.80 | IDO1 (0.58) | CHRM4DRD2HTR7ALDH1A1IDO1 | |
| SCHEMBL30290988 | 0.80 | IDO1 (0.58) | CHRM4DRD2HTR7ALDH1A1IDO1 | |
| SCHEMBL13165566 | 0.78 | CHRNB2 (0.41) | DRD2CHRNB2CHRNA4SIGMAR1KDM4C | |
| SCHEMBL19658410 | 0.77 | CHRNB2 (0.54) | CHRNB2CHRNA4SIGMAR1ALDH1A1TSHR | |
| SCHEMBL12993443 | 0.76 | SIGMAR1 (0.48) | DRD2CHRNB2CHRNA4SIGMAR1ALDH1A1 | |
| SCHEMBL2809491 | 0.76 | SIGMAR1 (0.48) | DRD2CHRNB2CHRNA4SIGMAR1ALDH1A1 | |
| SCHEMBL5051427 | 0.75 | ALDH1A1 (0.53) | ALDH1A1TSHR | |
| SCHEMBL12070481 | 0.75 | CHRM4 (0.44) | CHRM4DRD2HTR7KDM4CIDO1 | |
| SCHEMBL5051431 | 0.75 | ALDH1A1 (0.53) | ALDH1A1TSHR | |
| SCHEMBL3823105 | 0.74 | ESR1 (0.49) | CHRM4DRD2HTR7KDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1057814-B1 | TETRAHYDROBENZINDOLE DERIVATIVES | MEIJI SEIKA KAISHA (JP) | 2005-03-09 | — | — | EP | disclosed |
| US-6498251-B1 | Tetrahydrobenzindole derivatives | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-12-24 | — | — | US | disclosed |
| EP-1057814-A1 | TETRAHYDROBENZINDOLE DERIVATIVES | Meiji Seika Kaisha, Ltd. (JP) | 2000-12-06 | — | — | EP | disclosed |