Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.36 |
| ▸ | KDM4A | O75164 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6421708 | 0.85 | TLR8 (0.42) | TLR8MAP4K4ALDH1A1KDM4EPHF8 | |
| SCHEMBL8653720 | 0.85 | QPCT (0.42) | TLR8ALDH1A1KDM4EKDM4AKDM4C | |
| SCHEMBL8657334 | 0.84 | PDE10A (0.46) | TLR8PHF8KDM4CNPC1KDM5B | |
| SCHEMBL27368362 | 0.83 | MAP4K4 (0.39) | TLR8MAP4K4ALDH1A1KDM4EPHF8 | |
| SCHEMBL8656078 | 0.81 | MAPT (0.49) | TLR8ALDH1A1KDM4ENPC1MAPK1 | |
| SCHEMBL8093014 | 0.77 | TSHR (0.49) | ALDH1A1 | |
| SCHEMBL28895999 | 0.77 | CYP3A4 (0.54) | TLR8MAP4K4ALDH1A1KDM4EPHF8 | |
| SCHEMBL5514755 | 0.77 | ALDH1A1 (0.39) | ALDH1A1KDM5B | |
| SCHEMBL6423436 | 0.75 | CYP2A6 (0.65) | TLR8ALDH1A1 | |
| SCHEMBL8653314 | 0.72 | TLR8 (0.48) | TLR8ALDH1A1KDM4ENPC1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0680967-B1 | Erythromycin derivatives, their process of preparation and their use as medicaments | HOECHST MARION ROUSSEL INC (FR) | 1998-10-14 | — | — | EP | claimed |
| EP-0680967-A1 | Erythromycin derivatives, their process of preparation and their use as medicaments | ROUSSEL-UCLAF (FR) | 1995-11-08 | — | — | EP | claimed |
| WO-2005074945-A2 | KETOLIDE COMPOUNDS FOR THE TREATMENT OF ATHEROSCLEROSIS | CAMBRIDGE THERANOSTICS LIMITED (GB) | 2005-08-18 | — | — | WO | disclosed |
| EP-0680967-B1 | Erythromycin derivatives, their process of preparation and their use as medicaments | HOECHST MARION ROUSSEL INC (FR) | 1998-10-14 | — | — | EP | disclosed |
| EP-0680967-A1 | Erythromycin derivatives, their process of preparation and their use as medicaments | ROUSSEL-UCLAF (FR) | 1995-11-08 | — | — | EP | disclosed |