Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.59 |
| ▸ | RAB9A | P51151 | 7/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.56 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.50 |
| ▸ | METAP2 | P50579 | 1/20 | 0.50 |
| ▸ | STAT1 | P42224 | 1/20 | 0.50 |
| ▸ | F2RL3 | Q96RI0 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.48 |
| ▸ | RELA | Q04206 | 3/20 | 0.48 |
| ▸ | MAOB | P27338 | 3/20 | 0.47 |
| ▸ | MAOA | P21397 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5940898 | 0.78 | MAOB (0.57) | NPC1RAB9AMAPTSMN1; SMN2KDM4E | |
| SCHEMBL16720684 | 0.78 | NPC1 (0.37) | NPC1RAB9AMAPTCYP19A1GRM4 | |
| SCHEMBL31269859 | 0.75 | RAB9A (0.53) | NPC1RAB9AMAPTCYP19A1GRM4 | |
| SCHEMBL5328162 | 0.75 | NPC1 (1.00) | NPC1RAB9AMAPTCYP19A1GRM4 | |
| SCHEMBL29478404 | 0.74 | GRM4 (0.61) | NPC1RAB9AMAPTCYP19A1GRM4 | |
| SCHEMBL574760 | 0.74 | GRM4 (0.61) | NPC1RAB9AMAPTCYP19A1GRM4 | |
| SCHEMBL12647915 | 0.73 | NPC1 (0.69) | NPC1RAB9AMAPTCYP19A1GRM4 | |
| SCHEMBL29683802 | 0.73 | NPC1 (0.59) | NPC1RAB9AMAPTCYP19A1GRM4 | |
| SCHEMBL28566871 | 0.73 | NPC1 (0.59) | NPC1RAB9AMAPTCYP19A1GRM4 | |
| SCHEMBL103158 | 0.73 | MAOB (0.63) | NPC1RAB9AMAPTGRM4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6930104-B2 | Heterocyclic derivatives | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2005-08-16 | — | — | US | disclosed |
| US-20040157850-A1 | Novel heterocyclic derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-08-12 | — | — | US | disclosed |
| EP-1382598-A1 | NOVEL HETEROCYCLIC DERIVATIVES | Takeda Chemical Industries, Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040157850-A1 | Novel heterocyclic derivatives | APP, BACE1, PSEN1 | NPC1 207/4885RAB9A 2333/4885MAPT 186/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.