Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 1/20 | 0.61 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.60 |
| ▸ | AHR | P35869 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 4/20 | 0.56 |
| ▸ | RAB9A | P51151 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.54 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.54 |
| ▸ | METAP2 | P50579 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.50 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29478404 | 1.00 | GRM4 (0.61) | GRM4CYP19A1AHRNPC1RAB9A | |
| SCHEMBL17687570 | 0.81 | CYP19A1 (0.64) | GRM4CYP19A1NPC1RAB9AMAPT | |
| SCHEMBL31298375 | 0.81 | GRM4 (0.60) | GRM4CYP19A1NPC1RAB9AMAPT | |
| SCHEMBL4152709 | 0.81 | GRM4 (0.56) | GRM4CYP19A1NPC1RAB9AMAPT | |
| SCHEMBL29618952 | 0.81 | AHR (0.50) | GRM4CYP19A1AHRNPC1RAB9A | |
| SCHEMBL21295711 | 0.80 | AHR (0.47) | GRM4CYP19A1AHRNPC1RAB9A | |
| SCHEMBL5779426 | 0.80 | AHR (0.47) | GRM4CYP19A1AHRNPC1RAB9A | |
| SCHEMBL24776300 | 0.80 | KDM4E (0.54) | GRM4CYP19A1AHRNPC1RAB9A | |
| SCHEMBL1093099 | 0.80 | GRM4 (0.59) | GRM4CYP19A1NPC1RAB9AMAPT | |
| SCHEMBL8532513 | 0.80 | GRM4 (0.55) | GRM4CYP19A1NPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 130 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3129065-B1 | TARGETED DRUG DELIVERY THROUGH AFFINITY BASED LINKERS | AKAMARA THERAPEUTICS INC (US) | 2026-05-13 | — | — | EP | disclosed |
| EP-3876713-B1 | PATIENT-DERIVED AMYLOID XENOGRAFT RODENT MODEL | NEURIMMUNE AG (CH) | 2024-10-02 | — | — | EP | disclosed |
| US-12036291-B2 | Probes for imaging huntingtin protein | CHDI FOUNDATION, INC. (US) | 2024-07-16 | — | — | US | disclosed |
| CN-118005611-A | Probes for imaging huntingtin | CHDI基金会股份有限公司 | 2024-05-10 | — | — | CN | disclosed |
| CN-117430549-A | Method for preparing isonicotinic acid compound by taking carbon dioxide as carboxyl source | 南开大学 | 2024-01-23 | — | — | CN | disclosed |
| US-11851446-B2 | Probes for imaging Huntingtin protein | CHDI FOUNDATION, INC. (US) | 2023-12-26 | — | — | US | disclosed |
| CN-107074817-B | Probes for imaging huntingtin | CHDI基金会股份有限公司 | 2023-12-15 | — | — | CN | disclosed |
| US-20230382935-A1 | COMPOUND CONTAINING 1,3-DIKETONE LIGAND AND APPLICATION THEREOF, AND ORGANIC ELECTROLUMINESCENT DEVICE | BEIJING GREEN GUARDEE TECHNOLOGY CO., LTD. (CN) | 2023-11-30 | — | — | US | disclosed |
| US-20230382935-A1 | COMPOUND CONTAINING 1,3-DIKETONE LIGAND AND APPLICATION THEREOF, AND ORGANIC ELECTROLUMINESCENT DEVICE | BEIJING GREEN GUARDEE TECHNOLOGY CO., LTD. (CN) | 2023-11-30 | — | — | US | disclosed |
| US-20230382935-A1 | COMPOUND CONTAINING 1,3-DIKETONE LIGAND AND APPLICATION THEREOF, AND ORGANIC ELECTROLUMINESCENT DEVICE | BEIJING GREEN GUARDEE TECHNOLOGY CO., LTD. (CN) | 2023-11-30 | — | — | US | disclosed |
| US-6211219-B1 | DRUGS, ANALGESICS AND AGONISTS | MERCK SHARP & DOHME LTD. (GB) | 2001-04-03 | — | — | US | disclosed |
| WO-2000076990-A1 | NEW COMPOUNDS | ASTRAZENECA AB (SE) | 2000-12-21 | — | — | WO | disclosed |
| US-6127388-A | Azetidine, pyrrolidine and piperidine derivatives as 5-HT1D receptor agonists | MERCK SHARP & DOHME LTD. (GB) | 2000-10-03 | — | — | US | disclosed |
| US-5837715-A | 3-fluoro-4-aminopiperidine derivatives as 5-HT receptor agonists | MERCK SHARP & DOHME LTD. (GB) | 1998-11-17 | — | — | US | disclosed |
| US-4600719-A | Tetrahydropyridine and piperidine derivatives | CIBA GEIGY CORPORATION (US) | 1986-07-15 | — | — | US | disclosed |
| US-4495357-A | THROMBOXANE A2 SYNTHETASE INHIBITORS | THE UPJOHN COMPANY (US) | 1985-01-22 | — | — | US | disclosed |
| US-4490531-A | THROMBOXAN INHIBITOR, ANTITUMOR AGENT, HYPOTENSIVE AGENT | THE UPJOHN COMPANY (US) | 1984-12-25 | — | — | US | disclosed |
| US-4455427-A | THROMBOXANE INHIBITORS | THE UPJOHN COMPANY (US) | 1984-06-19 | — | — | US | disclosed |
| EP-0069521-A2 | Pyridinyl and imidazolyl derivatives of benzofurans and benzothiophenes | THE UPJOHN COMPANY (US) | 1983-01-12 | — | — | EP | disclosed |
| US-4210655-A | Anti-depressant benzofuranyl piperidines | CIBA-GEIGY CORPORATION (US) | 1980-07-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11851446-B2 | Probes for imaging Huntingtin protein | HTT, HYPK, HSPBP1 | GRM4 2066/4885CYP19A1 4704/4885AHR 2207/4885 |
| US-12036291-B2 | Probes for imaging huntingtin protein | HTT, HYPK, HSPBP1 | GRM4 2066/4885CYP19A1 4704/4885AHR 2207/4885 |
| US-20230382935-A1 | COMPOUND CONTAINING 1,3-DIKETONE LIGAND AND APPLICATION THEREOF, AND ORGANIC ELECTROLUMINESCENT DEVICE | TLK1, TLK2, PDK3 | GRM4 1758/4885CYP19A1 3126/4885AHR 3450/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.