Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 6/20 | 0.72 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.72 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.72 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.72 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.72 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.72 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.72 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.72 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.72 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.72 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.72 |
| ▸ | HTR6 | P50406 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.50 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.50 |
| ▸ | PPARG | P37231 | 2/20 | 0.46 |
| ▸ | PPARA | Q07869 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7066710 | 0.90 | HDAC1 (0.71) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL6866199 | 0.90 | HDAC3 (0.69) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL7061803 | 0.89 | HDAC1 (0.69) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL6865379 | 0.86 | HDAC3 (0.66) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL430164 | 0.85 | HDAC1 (0.65) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL17927522 | 0.85 | HTR6 (0.69) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL17927510 | 0.85 | HDAC1 (0.64) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL17927570 | 0.84 | HDAC3 (0.64) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL17927541 | 0.84 | MEN1 (0.64) | HDAC1HDAC6HDAC3HDAC4HDAC7 | |
| SCHEMBL1443617 | 0.83 | HDAC3 (0.62) | HDAC1HDAC6HDAC3HDAC4HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050227978-A1 | Fibrosis inhibitor | SUMITOMO PHARMACEUTICALS CO., LTD. (JP) | 2005-10-13 | — | — | US | disclosed |
| EP-1479384-A1 | FIBROSIS INHIBITOR | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2004-11-24 | — | — | EP | disclosed |
| US-20040209939-A1 | Pyrrole derivatives | SUMITOMO PHARMACEUTICALS CO., LTD. | 2004-10-21 | — | — | US | disclosed |
| US-6759429-B2 | HAVING TRANSFORMING GROWTH FACTOR- BETA INHIBITORY ACTIVITY AND BEING USEFUL AS FIBROSIS INHIBITORS FOR ORGANS OR TISSUES | SUMITOMO PHARMACEUTICALS CO., LTD. (JP) | 2004-07-06 | — | — | US | disclosed |
| US-20030181496-A1 | Pyrrole derivatives | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2003-09-25 | — | — | US | disclosed |
| EP-1310485-A1 | PYRROLE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2003-05-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050227978-A1 | Fibrosis inhibitor | SMAD3, MMP1, SMAD2 | HDAC1 17/4885HDAC6 89/4885HDAC3 70/4885 |
| US-20030181496-A1 | Pyrrole derivatives | NCOA1, PKD1, NR3C2 | HDAC1 51/4885HDAC6 264/4885HDAC3 109/4885 |
| US-20040209939-A1 | Pyrrole derivatives | NCOA1, PKD1, NCOR1 | HDAC1 50/4885HDAC6 299/4885HDAC3 112/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.