SCHEMBL6423396

SCHEMBL6423396

C#CCC(=O)OCCOC(=O)CC#C

nearest known ligand 0.36

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
DGKA P23743 1/20 0.36
TSHR P16473 1/20 0.33
ADRA2A P08913 1/20 0.33
ADRA1A P35348 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
GSTP1 P09211 1/20 0.33
NPC1 O15118 1/20 0.32
MAPT P10636 1/20 0.32
BLM P54132 1/20 0.32
NAAA Q02083 1/20 0.31
CYP2C19 P33261 1/20 0.31
MEN1 O00255 1/20 0.31
KMT2A Q03164 1/20 0.31
ALDH1A1 P00352 1/20 0.30
L3MBTL1 Q9Y468 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6422929 0.92 TSHR (0.39) DGKATSHRADRA2AADRA1ATDP1
SCHEMBL29094028 0.89 NAAA (0.43) DGKATSHRADRA2AADRA1ATDP1
SCHEMBL17404784 0.89 NAAA (0.38) DGKATSHRADRA2AADRA1ATDP1
SCHEMBL10011077 0.87 MEN1 (0.43) TSHRADRA2AADRA1AMAPTCYP2C19
SCHEMBL7226506 0.85
SCHEMBL9025731 0.85
SCHEMBL16024226 0.83 MAPT (0.40) TSHRMAPTNAAACYP2C19MEN1
SCHEMBL10010587 0.81 MEN1 (0.33) MEN1KMT2A
SCHEMBL7105216 0.81 ALDH1A1 (0.52) DGKATSHRTDP1NAAAMEN1
SCHEMBL10010450 0.80

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050281968-A1 Energetic structural material ALLIANT TECHSYSTEMS INC. (US) 2005-12-22 US claimed
US-20050281968-A1 Energetic structural material ALLIANT TECHSYSTEMS INC. (US) 2005-12-22 US disclosed