SCHEMBL6422929

SCHEMBL6422929

C#CCC(=O)OCCOCCOC(=O)CC#C

nearest known ligand 0.39

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
TSHR P16473 4/20 0.39
ALDH1A1 P00352 3/20 0.39
TP53 P04637 2/20 0.39
HIF1A Q16665 2/20 0.39
HSD17B10 Q99714 1/20 0.39
SERPINE1 P05121 1/20 0.32
DGKA P23743 1/20 0.32
GSTP1 P09211 1/20 0.31
TDP1 Q9NUW8 1/20 0.30
THRB P10828 1/20 0.30
ADRA2A P08913 1/20 0.30
ADRA1A P35348 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6423396 0.92 DGKA (0.36) TSHRALDH1A1DGKAGSTP1TDP1
SCHEMBL17404784 0.82 NAAA (0.38) TSHRALDH1A1SERPINE1DGKAGSTP1
SCHEMBL29094028 0.82 NAAA (0.43) TSHRALDH1A1DGKAGSTP1TDP1
SCHEMBL10011077 0.80 MEN1 (0.43) TSHRHSD17B10ADRA2AADRA1A
SCHEMBL6418312 0.79 DGKA (0.38) TSHRALDH1A1TP53HIF1AHSD17B10
SCHEMBL7226506 0.78
SCHEMBL13557224 0.78 MCL1 (0.39) TSHRALDH1A1TP53HIF1AHSD17B10
SCHEMBL9025731 0.78
SCHEMBL3785372 0.78 MCL1 (0.39) TSHRALDH1A1TP53HIF1AHSD17B10
SCHEMBL16024226 0.76 MAPT (0.40) TSHRALDH1A1TP53HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050281968-A1 Energetic structural material ALLIANT TECHSYSTEMS INC. (US) 2005-12-22 US claimed
US-20050281968-A1 Energetic structural material ALLIANT TECHSYSTEMS INC. (US) 2005-12-22 US disclosed