Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 2/20 | 0.37 |
| ▸ | CES1 | P23141 | 2/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 6/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 6/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 6/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 6/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 6/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 6/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 2/20 | 0.32 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.32 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4432794 | 0.87 | CES2 (0.37) | CES2CES1RIPK1ACKR3HTT | |
| SCHEMBL4425980 | 0.76 | AOC3 (0.40) | HTTOPRM1KMT2AL3MBTL1 | |
| SCHEMBL4435860 | 0.75 | CES2 (0.36) | CES2CES1OPRM1MAPTOPRL1 | |
| SCHEMBL3829073 | 0.74 | OPRM1 (0.47) | OPRM1OPRL1 | |
| SCHEMBL4429231 | 0.74 | CES2 (0.41) | CES2CES1RIPK1OPRM1 | |
| SCHEMBL4593455 | 0.74 | CES2 (0.41) | CES2CES1PSEN1PSEN2APH1B | |
| SCHEMBL6421263 | 0.73 | CES2 (0.32) | CES2CES1OPRM1OPRL1 | |
| SCHEMBL20640522 | 0.67 | APLNR (0.39) | CES2CES1PSEN1PSEN2APH1B | |
| SCHEMBL31257263 | 0.67 | APLNR (0.39) | CES2CES1PSEN1PSEN2APH1B | |
| SCHEMBL19801164 | 0.67 | NISCH (0.38) | HTTOPRM1MEN1HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1527050-A1 | QUINOLINE DERIVATIVES AND THEIR USE AS MYCOBACTERIAL INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-05-04 | — | — | EP | disclosed |
| WO-2004011436-A1 | QUINOLINE DERIVATIVES AND THEIR USE AS MYCOBACTERIAL INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2004-02-05 | — | — | WO | disclosed |