Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 6/20 | 0.48 |
| ▸ | AKR1C2 | P52895 | 6/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5560180 | 0.92 | AKR1C3 (0.49) | AKR1C3AKR1C2PTGS1PTGS2LMNA | |
| SCHEMBL5559181 | 0.91 | AKR1C3 (0.49) | AKR1C3AKR1C2PTGS1PLA2G4APTGS2 | |
| SCHEMBL5560656 | 0.89 | AKR1C3 (0.50) | AKR1C3AKR1C2PTGS1PLA2G4APTGS2 | |
| SCHEMBL5559639 | 0.88 | AKR1C3 (0.54) | AKR1C3AKR1C2PTGS1PTGS2LMNA | |
| SCHEMBL5814583 | 0.87 | AKR1C3 (0.44) | AKR1C3AKR1C2PTGS1THRBPLA2G4A | |
| SCHEMBL5553809 | 0.87 | AKR1C3 (0.50) | AKR1C3AKR1C2PTGS1PLA2G4APTGS2 | |
| SCHEMBL5555236 | 0.87 | AKR1C3 (0.50) | AKR1C3AKR1C2PTGS1PLA2G4APTGS2 | |
| SCHEMBL5559738 | 0.86 | AKR1C3 (0.61) | AKR1C3AKR1C2PTGS1PTGS2LMNA | |
| SCHEMBL5554588 | 0.85 | AKR1C3 (0.44) | AKR1C3AKR1C2PTGS1PTGS2LMNA | |
| SCHEMBL5559502 | 0.85 | AKR1C3 (0.44) | AKR1C3AKR1C2PTGS1THRBPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050234244-A1 | Synthesis of COX-2 and FAAH inhibitors | IRONWOOD PHARMACEUTICALS, INC. | 2005-10-20 | — | — | US | disclosed |
| US-20050032747-A1 | COX-2 and FAAH inhibitors | POLYMER CONCEPTS TECHNOLOGIES PBY, INC. | 2005-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050032747-A1 | COX-2 and FAAH inhibitors | FAAH2, FAAH, PTGS2 | AKR1C3 585/4885AKR1C2 342/4885PTGS1 6/4885 |
| US-20050234244-A1 | Synthesis of COX-2 and FAAH inhibitors | FAAH2, FAAH, PTGES2 | AKR1C3 577/4885AKR1C2 563/4885PTGS1 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.