Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 5/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.43 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PPARD | Q03181 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 2/20 | 0.35 |
| ▸ | PRKACA | P17612 | 2/20 | 0.35 |
| ▸ | PRKACG | P22612 | 2/20 | 0.35 |
| ▸ | PRKACB | P22694 | 2/20 | 0.35 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6424433 | 0.98 | AKR1C3 (0.43) | AKR1C3AKR1C2MAPK7MTNR1BMDM2 | |
| SCHEMBL6425909 | 0.91 | PTGS2 (0.39) | AKR1C3AKR1C2MAPK7PTGS1PTGS2 | |
| SCHEMBL6423785 | 0.91 | AKR1C3 (0.41) | AKR1C3AKR1C2MAPK7PTGS1PTGS2 | |
| SCHEMBL6425163 | 0.91 | PTGS2 (0.48) | AKR1C3AKR1C2MAPK7MTNR1BMDM2 | |
| SCHEMBL6427114 | 0.90 | PPARG (0.42) | AKR1C3AKR1C2MAPK7PPARGPPARA | |
| SCHEMBL6425200 | 0.90 | PTGS2 (0.38) | AKR1C3AKR1C2MAPK7PTGS1PTGS2 | |
| SCHEMBL6424441 | 0.89 | AKR1C3 (0.41) | AKR1C3AKR1C2MAPK7PTGS1PTGS2 | |
| SCHEMBL6426648 | 0.89 | PTGS2 (0.39) | AKR1C3AKR1C2MAPK7PTGS1PTGS2 | |
| SCHEMBL6426763 | 0.89 | PTGS2 (0.48) | AKR1C3AKR1C2MAPK7MTNR1BMDM2 | |
| SCHEMBL6426816 | 0.89 | SRC (0.42) | AKR1C3AKR1C2MDM2SRCPRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050234244-A1 | Synthesis of COX-2 and FAAH inhibitors | IRONWOOD PHARMACEUTICALS, INC. | 2005-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050234244-A1 | Synthesis of COX-2 and FAAH inhibitors | FAAH2, FAAH, PTGES2 | AKR1C3 577/4885AKR1C2 563/4885MAPK7 2506/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.