Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | LPL | P06858 | 1/20 | 0.37 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5304573 | 0.97 | TP53 (0.48) | TP53TAAR1SMN1; SMN2HTTKDM4E | |
| SCHEMBL12160588 | 0.83 | ALDH1A1 (0.37) | TP53SMN1; SMN2HTTKDM4ENPC1 | |
| Iodide SCHEMBL3377972 | 0.80 | KDM4E (0.56) | TP53SMN1; SMN2HTTKDM4ENPC1 | |
| SCHEMBL28117051 | 0.79 | LOXL2 (0.42) | TAAR1 | |
| SCHEMBL5294787 | 0.79 | LPL (0.41) | TP53TAAR1SMN1; SMN2HTTKDM4E | |
| SCHEMBL294241 | 0.79 | CHKA (0.52) | TP53SMN1; SMN2HTTKDM4ENPC1 | |
| Iodide SCHEMBL1502806 | 0.78 | HTT (0.54) | TP53SMN1; SMN2HTTKDM4ENPC1 | |
| SCHEMBL5288200 | 0.78 | TP53 (0.46) | TP53TAAR1SMN1; SMN2HTTKDM4E | |
| Hydrochloric Acid SCHEMBL18604139 | 0.77 | LPL (0.40) | TP53TAAR1LPLLIPGCYP2C9 | |
| SCHEMBL1305882 | 0.77 | MEN1 (0.54) | TP53SMN1; SMN2HTTKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047674-B1 | PROCESS FOR PRODUCTION OF DONEPEZIL DERIVATIVES | EISAI CO LTD (JP) | 2005-03-30 | — | — | EP | disclosed |