Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.34 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.34 |
| ▸ | GRN | P28799 | 1/20 | 0.34 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.32 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6425591 | 1.00 | ABCB11 (0.34) | ABCB11AKR1C3AKR1C2GRNSORT1 | |
| SCHEMBL6456480 | 0.94 | AKR1C3 (0.33) | ABCB11AKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL6462238 | 0.94 | AKR1C3 (0.33) | ABCB11AKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL6425032 | 0.92 | GRN (0.40) | ABCB11AKR1C3AKR1C2GRNSORT1 | |
| SCHEMBL6424377 | 0.92 | ABCB11 (0.37) | ABCB11AKR1C3AKR1C2GRNSORT1 | |
| SCHEMBL6424865 | 0.92 | ABCB11 (0.37) | ABCB11AKR1C3AKR1C2GRNSORT1 | |
| SCHEMBL6423563 | 0.90 | AKR1C3 (0.41) | ABCB11AKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL6423900 | 0.90 | AKR1C3 (0.41) | ABCB11AKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL6425256 | 0.89 | GRN (0.34) | AKR1C3AKR1C2GRNSORT1PSEN1 | |
| SCHEMBL6424917 | 0.89 | GRN (0.34) | AKR1C3AKR1C2GRNSORT1PSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050234244-A1 | Synthesis of COX-2 and FAAH inhibitors | IRONWOOD PHARMACEUTICALS, INC. | 2005-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050234244-A1 | Synthesis of COX-2 and FAAH inhibitors | FAAH2, FAAH, PTGES2 | ABCB11 4380/4885AKR1C3 577/4885AKR1C2 563/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.