Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 9/20 | 0.35 |
| ▸ | ACACB | O00763 | 3/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 8/20 | 0.33 |
| ▸ | AKR1C2 | P52895 | 7/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.33 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | CDC42 | P60953 | 1/20 | 0.33 |
| ▸ | RAC1 | P63000 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | ALB | P02768 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | RARB | P10826 | 1/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5738491 | 0.83 | FFAR1 (0.44) | ACACBFFAR1NR1H4 | |
| SCHEMBL7985131 | 0.79 | ACE2 (0.33) | ACACB | |
| SCHEMBL5735231 | 0.79 | ACACB (0.41) | ACACBTSHRLMNACYP1A2ESR1 | |
| SCHEMBL6427160 | 0.72 | PTGS2 (0.41) | PTGS2ACACBAKR1C3AKR1C2PTGS1 | |
| SCHEMBL6427700 | 0.72 | PTGS2 (0.41) | PTGS2AKR1C3AKR1C2PTGS1TSHR | |
| SCHEMBL6426393 | 0.70 | PTGS2 (0.36) | PTGS2ACACBAKR1C3AKR1C2PTGS1 | |
| SCHEMBL6426327 | 0.69 | ACACB (0.40) | PTGS2ACACBAKR1C3AKR1C2PTGS1 | |
| SCHEMBL6426280 | 0.67 | PTGS2 (0.41) | PTGS2ACACBAKR1C3AKR1C2RARB | |
| SCHEMBL6426325 | 0.67 | ACACB (0.38) | PTGS2ACACBAKR1C3AKR1C2PTGS1 | |
| SCHEMBL458764 | 0.67 | AKR1C3 (0.64) | PTGS2ACACBAKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6855512-B2 | Methods for identifying inhibitors of cytochrome P450RAI | ALLERGAN, INC. (US) | 2005-02-15 | — | — | US | disclosed |
| US-6369225-B1 | ENZYME INHIBITORS | ALLERGAN SALES, INC. | 2002-04-09 | — | — | US | disclosed |
| US-6369261-B1 | CYCLOPROPYLBENZENE DERIVATIVE OF ACIDS OR ESTERS | ALLERGAN SALES, INC. | 2002-04-09 | — | — | US | disclosed |
| US-6303785-B1 | SUBSTITUTED N-CYCLOPROPYLTETRAHYDROISOQUINOLINES | ALLERGAN SALES, INC. | 2001-10-16 | — | — | US | disclosed |