Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 4/20 | 0.60 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.60 |
| ▸ | PTPN6 | P29350 | 2/20 | 0.60 |
| ▸ | CFTR | P13569 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 8/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | ESR1 | P03372 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 6/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6428107 | 0.83 | CFTR (0.50) | PTPN1PTPN2PTPN6CFTRPOLB | |
| SCHEMBL6963441 | 0.79 | PTPN1 (0.57) | PTPN1PTPN2PTPN6CFTRPOLB | |
| SCHEMBL18519819 | 0.76 | ALDH1A1 (0.48) | PTPN1PTPN2PTPN6POLBKDM4E | |
| SCHEMBL6963436 | 0.76 | PTPN1 (0.49) | PTPN1PTPN2PTPN6CFTRPOLB | |
| SCHEMBL29955759 | 0.76 | FOLH1 (0.54) | PTPN1PTPN2PTPN6ALDH1A1HSD17B10 | |
| SCHEMBL15331022 | 0.76 | FOLH1 (0.54) | PTPN1PTPN2PTPN6ALDH1A1HSD17B10 | |
| SCHEMBL1673212 | 0.75 | PTPN1 (0.54) | PTPN1PTPN2PTPN6CFTRPOLB | |
| SCHEMBL8846999 | 0.74 | ALDH1A1 (0.44) | PTPN1PTPN2PTPN6POLBKDM4E | |
| SCHEMBL4141035 | 0.73 | PTPN1 (0.51) | PTPN1PTPN2PTPN6CFTRPOLB | |
| SCHEMBL6644180 | 0.73 | ERN1 (0.50) | PTPN1PTPN2PTPN6CFTRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050042674-A9 | Common ligand mimics: thiazolidinediones and rhodanines | TRIAD THERAPEUTICS, INC. | 2005-02-24 | — | — | US | disclosed |
| US-20040009526-A1 | Common ligand mimics: thiazolidinediones and rhodanines | YU LIN (US) | 2004-01-15 | — | — | US | disclosed |
| WO-2003072033-A2 | COMMON LIGAND MIMICS: THIAZOLIDINEDIONES AND RHODANINES | TRIAD THERAPEUTICS, INC. (US) | 2003-09-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040009526-A1 | Common ligand mimics: thiazolidinediones and rhodanines | GPR65, NR2E3, FGFR3 | PTPN1 1174/4885PTPN2 977/4885PTPN6 1019/4885 |
| US-20050042674-A9 | Common ligand mimics: thiazolidinediones and rhodanines | GPR65, NR2E3, FGFR3 | PTPN1 1174/4885PTPN2 977/4885PTPN6 1019/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.