Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CDC25C | P30307 | 1/20 | 0.36 |
| ▸ | SNCA | P37840 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28623192 | 0.83 | TSHR (0.49) | ALDH1A1MAPTKDM4ETTRPOLB | |
| SCHEMBL30208637 | 0.83 | TSHR (0.49) | ALDH1A1MAPTKDM4ETTRPOLB | |
| SCHEMBL25784409 | 0.80 | TSHR (0.53) | ALDH1A1MAPTKDM4ESIGMAR1SMN1; SMN2 | |
| SCHEMBL23861124 | 0.79 | TSHR (0.50) | ALDH1A1MAPTKDM4EPOLBSIGMAR1 | |
| SCHEMBL30060723 | 0.79 | TSHR (0.50) | ALDH1A1MAPTKDM4EPOLBSIGMAR1 | |
| Dimethylamine SCHEMBL7133569 | 0.77 | MAPT (0.46) | ALDH1A1MAPTTTRSMN1; SMN2GAA | |
| SCHEMBL6382390 | 0.77 | ALDH3A1 (0.51) | ALDH1A1MAPTTTRSIGMAR1SMN1; SMN2 | |
| SCHEMBL7262800 | 0.76 | ALDH1A1 (0.60) | ALDH1A1SIGMAR1SMN1; SMN2TSHR | |
| SCHEMBL19639766 | 0.75 | VCAM1 (0.48) | ALDH1A1MAPTSIGMAR1SMN1; SMN2NPSR1 | |
| SCHEMBL23861121 | 0.75 | MEN1 (0.44) | ALDH1A1MAPTKDM4EPOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1131301-B1 | 2-PHENYLBENZIMIDAZOLES AND 2-PHENYLINDOLES, AND PRODUCTION AND USE THEREOF | ABBOTT GMBH & CO KG (DE) | 2005-08-24 | — | — | EP | disclosed |
| US-6509365-B1 | 2-phenylbenzimidazoles and 2-phenylindoles, and production and use thereof | BASF AKTIENGESELLSCHAFT (DE) | 2003-01-21 | — | — | US | disclosed |