Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 3/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.59 |
| ▸ | GSK3A | P49840 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RGS4 | P49798 | 1/20 | 0.46 |
| ▸ | RGS8 | P57771 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ELANE | P08246 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | GSR | P00390 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30893118 | 1.00 | GSK3B (0.59) | GSK3BHDAC6GSK3AMAPTALDH1A1 | |
| SCHEMBL29239097 | 0.80 | GSK3B (0.71) | GSK3BHDAC6GSK3AMAPTALDH1A1 | |
| SCHEMBL29239077 | 0.79 | GSK3B (0.64) | GSK3BHDAC6GSK3AALDH1A1RGS4 | |
| SCHEMBL14950547 | 0.78 | RGS4 (0.54) | GSK3BHDAC6GSK3AMAPTALDH1A1 | |
| SCHEMBL29239059 | 0.76 | GSK3B (0.76) | GSK3BHDAC6GSK3ARGS4RGS8 | |
| Tideglusib SCHEMBL29357303 | 0.75 | GSK3B (1.00) | GSK3BHDAC6GSK3ARGS4RGS8 | |
| Tideglusib SCHEMBL676929 | 0.75 | GSK3B (1.00) | GSK3BHDAC6GSK3ARGS4RGS8 | |
| SCHEMBL29239076 | 0.74 | GSK3B (0.81) | GSK3BHDAC6RGS4RGS8TDP1 | |
| SCHEMBL29239083 | 0.72 | GSK3B (0.83) | GSK3BHDAC6GSK3ARGS4RGS8 | |
| SCHEMBL14941895 | 0.72 | RGS4 (0.70) | GSK3BGSK3AMAPTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113827592-B | Application of thiadiazolidinedione compound in treating pathogenic infection | 中国科学院上海药物研究所 | 2024-06-18 | — | — | CN | disclosed |
| WO-2005024755-A2 | MEDICAMENTS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS OR DIABETES | DECIPHERA PHARMACEUTICALS, LLC. (US) | 2005-03-17 | — | — | WO | disclosed |