Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMD14 | O00487 | 1/20 | 0.54 |
| ▸ | STAMBP | O95630 | 1/20 | 0.54 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 6/20 | 0.51 |
| ▸ | RAB9A | P51151 | 6/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13927634 | 0.90 | HPGD (0.58) | PSMD14STAMBPCOPS5HPGDRAB9A | |
| SCHEMBL4333976 | 0.84 | MEN1 (0.51) | HPGDRAB9ANPC1HTTKDM4E | |
| SCHEMBL4345592 | 0.84 | MEN1 (0.51) | HPGDRAB9ANPC1HTTKDM4E | |
| SCHEMBL4336801 | 0.79 | GSK3B (0.54) | HPGDRAB9ANPC1HTTKDM4E | |
| SCHEMBL4338646 | 0.79 | GSK3B (0.54) | HPGDRAB9ANPC1HTTKDM4E | |
| SCHEMBL4151588 | 0.79 | HPGDS (0.47) | HPGDRAB9ANPC1HTTKMT2A | |
| SCHEMBL13927647 | 0.79 | HTT (0.59) | HPGDRAB9ANPC1HTTKDM4E | |
| SCHEMBL6426385 | 0.77 | HDAC3 (0.41) | RAB9ANPC1 | |
| SCHEMBL4333955 | 0.77 | KDM4E (0.56) | HPGDRAB9ANPC1KDM4EHSD17B10 | |
| SCHEMBL6428817 | 0.76 | ALDH1A1 (0.52) | PSMD14STAMBPCOPS5HPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7429609-B2 | Pyrazole compound and medicinal composition containing the same | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2008-09-30 | — | — | US | disclosed |
| US-7429609-B2 | Pyrazole compound and medicinal composition containing the same | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2008-09-30 | — | — | US | disclosed |
| US-20050261339-A1 | Pyrazole compound and medicinal composition containing the same | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2005-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050261339-A1 | Pyrazole compound and medicinal composition containing the same | CNKSR1, NR3C2, CSNK2B | PSMD14 4340/4885STAMBP 2938/4885COPS5 1499/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.