Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18876187 | 0.79 | CYP19A1 (0.33) | GRM2ADRA1DADRA1AADRA1BCYP19A1 | |
| SCHEMBL5135531 | 0.79 | ADRA1A (0.37) | GRM2ADRA1DADRA1AADRA1BCYP19A1 | |
| Hydrochloric Acid SCHEMBL5140983 | 0.77 | ADRA1A (0.38) | GRM2ADRA1DADRA1AADRA1BCYP19A1 | |
| SCHEMBL14510188 | 0.75 | ADRA1A (0.42) | GRM2ADRA1DADRA1AADRA1B | |
| SCHEMBL18876176 | 0.71 | KDM4E (0.38) | GRM2CYP19A1 | |
| SCHEMBL21725647 | 0.70 | GRM2 (0.37) | GRM2 | |
| SCHEMBL18876129 | 0.69 | GRM2 (0.37) | GRM2 | |
| SCHEMBL29277331 | 0.68 | GRM2 (0.37) | GRM2 | |
| SCHEMBL7920908 | 0.67 | TTR (0.44) | — | |
| SCHEMBL18876179 | 0.66 | GRM2 (0.35) | GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1545543-A2 | NOVEL TYROSINE KINASES INHIBITORS | Bristol-Myers Squibb Company (US) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004031401-A2 | NOVEL TYROSINE KINASES INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-04-15 | — | — | WO | disclosed |