Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | TBXAS1 | P24557 | 7/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8479597 | 0.84 | CHRNA7 (0.46) | KDM4ENAPRTCYP1A2CYP2D6TBXAS1 | |
| SCHEMBL6450627 | 0.80 | FDPS (0.45) | FDPSNAPRTCYP1A2CYP2D6CHRNA7 | |
| SCHEMBL9257518 | 0.79 | FDPS (0.54) | FDPSKDM4ENAPRTCYP1A2CYP2D6 | |
| SCHEMBL15184715 | 0.78 | TRPA1 (0.44) | CYP1A2 | |
| SCHEMBL15184700 | 0.78 | TRPA1 (0.44) | CYP1A2 | |
| SCHEMBL2369596 | 0.78 | TRPA1 (0.44) | CYP1A2 | |
| SCHEMBL30456305 | 0.77 | FDPS (0.53) | FDPSKDM4ENAPRTCYP1A2CYP2D6 | |
| SCHEMBL14665072 | 0.77 | FDPS (0.53) | FDPSKDM4ENAPRTCYP1A2CYP2D6 | |
| SCHEMBL4726907 | 0.77 | FDPS (0.56) | FDPSKDM4ENAPRTCYP1A2CYP2D6 | |
| SCHEMBL9547411 | 0.76 | FDPS (0.59) | FDPSKDM4ENAPRTCYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1086082-B9 | ARYLSUBSTITUTED OLEFINIC AMINES AND THEIR USE AS CHOLINERGIC RECEPTORS AGONISTS | TARGACEPT INC (US) | 2005-03-02 | — | — | EP | disclosed |
| EP-1086082-B1 | ARYLSUBSTITUTED OLEFINIC AMINES AND THEIR USE AS CHOLINERGIC RECEPTORS AGONISTS | TARGACEPT INC (US) | 2004-08-18 | — | — | EP | disclosed |