Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.73 |
| ▸ | MEN1 | O00255 | 7/20 | 0.73 |
| ▸ | NPC1 | O15118 | 6/20 | 0.73 |
| ▸ | RAB9A | P51151 | 6/20 | 0.73 |
| ▸ | CASP3 | P42574 | 2/20 | 0.73 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.73 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.73 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.73 |
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | MITF | O75030 | 1/20 | 0.60 |
| ▸ | TNF | P01375 | 1/20 | 0.60 |
| ▸ | CRHBP | P24387 | 1/20 | 0.60 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.60 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.60 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.58 |
| ▸ | DUSP3 | P51452 | 2/20 | 0.58 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4918045 | 0.79 | RAB9A (1.00) | KMT2AMEN1NPC1RAB9ACASP3 | |
| SCHEMBL2115414 | 0.78 | MEN1 (0.68) | KMT2AMEN1NPC1RAB9ACASP3 | |
| SCHEMBL16562118 | 0.78 | RAB9A (1.00) | KMT2AMEN1NPC1RAB9ACASP3 | |
| SCHEMBL22822539 | 0.76 | LMNA (0.70) | KMT2AMEN1NPC1RAB9APOLB | |
| SCHEMBL3045307 | 0.76 | DUSP3 (0.82) | KMT2AMEN1NPC1RAB9ACASP3 | |
| SCHEMBL20660046 | 0.75 | DYRK1A (0.80) | KMT2AMEN1NPC1RAB9APOLB | |
| SCHEMBL15376502 | 0.75 | DYRK1A (1.00) | KMT2AMEN1NPC1RAB9APOLB | |
| SCHEMBL3047328 | 0.75 | DYRK1A (0.80) | KMT2AMEN1NPC1RAB9APOLB | |
| SCHEMBL3054015 | 0.74 | DUSP3 (0.76) | KMT2AMEN1NPC1RAB9ACASP3 | |
| SCHEMBL2117303 | 0.74 | MEN1 (0.71) | KMT2AMEN1NPC1RAB9ACASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050026968-A1 | Heterocyclic amides with anti-tuberculosis activity | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION | 2005-02-03 | — | — | US | claimed |
| US-20050222408-A1 | Heterocyclic amides with anti-tuberculosis activity | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION | 2005-10-06 | — | — | US | disclosed |
| US-20050026968-A1 | Heterocyclic amides with anti-tuberculosis activity | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION | 2005-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050222408-A1 | Heterocyclic amides with anti-tuberculosis activity | TST, KAT5, NDUFS5 | KMT2A 2545/4885MEN1 4703/4885NPC1 1957/4885 |
| US-20050026968-A1 | Heterocyclic amides with anti-tuberculosis activity | TST, KAT5, HDAC5 | KMT2A 2476/4885MEN1 4749/4885NPC1 1752/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.