Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 19/20 | 0.41 |
| ▸ | FPR3 | P25089 | 2/20 | 0.32 |
| ▸ | TSPO | P30536 | 2/20 | 0.32 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6429243 | 0.72 | CRHR1 (0.50) | CRHR1FPR3TSPOTMEM97TDP1 | |
| SCHEMBL5844836 | 0.70 | CRHR1 (0.55) | CRHR1 | |
| SCHEMBL5843903 | 0.68 | CRHR1 (0.57) | CRHR1FPR3TSPOTMEM97TDP1 | |
| SCHEMBL12963494 | 0.66 | RAPGEF4 (0.50) | CRHR1TDP1 | |
| SCHEMBL3636751 | 0.66 | RAPGEF4 (0.41) | CRHR1TDP1 | |
| SCHEMBL2360359 | 0.64 | CRHR1 (0.46) | CRHR1 | |
| SCHEMBL6429736 | 0.62 | CRHR1 (0.36) | CRHR1FPR3TSPOTMEM97TDP1 | |
| SCHEMBL6444145 | 0.60 | CRHR1 (0.33) | CRHR1 | |
| SCHEMBL19908710 | 0.60 | CNR2 (0.36) | CRHR1TDP1 | |
| SCHEMBL5845676 | 0.59 | RAPGEF4 (0.52) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6844351-B1 | Corticotropin releasing factor antagonists | PFIZER INC. (US) | 2005-01-18 | — | — | US | disclosed |