Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 11/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6429736 | 0.86 | CRHR1 (0.36) | CRHR1 | |
| SCHEMBL5776917 | 0.68 | NOS2 (0.41) | CRHR1 | |
| SCHEMBL5431809 | 0.68 | — | — | |
| SCHEMBL5844680 | 0.66 | LMNA (0.33) | CRHR1HTT | |
| SCHEMBL6428273 | 0.60 | CRHR1 (0.41) | CRHR1 | |
| SCHEMBL18551663 | 0.60 | SIGMAR1 (0.40) | — | |
| SCHEMBL22704314 | 0.59 | MEN1 (0.48) | HTT | |
| SCHEMBL21447163 | 0.59 | CRHR1 (0.48) | CRHR1 | |
| SCHEMBL5844836 | 0.59 | CRHR1 (0.55) | CRHR1 | |
| SCHEMBL22699501 | 0.58 | ADORA1 (0.34) | CRHR1HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6844351-B1 | Corticotropin releasing factor antagonists | PFIZER INC. (US) | 2005-01-18 | — | — | US | disclosed |