Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.34 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5845086 | 0.77 | CRHR1 (0.46) | CRHR1 | |
| SCHEMBL6428338 | 0.74 | LMNA (0.38) | LMNAGAACRHR1RAPGEF4 | |
| SCHEMBL123666 | 0.67 | CRHR1 (0.58) | CRHR1 | |
| SCHEMBL5600278 | 0.65 | CRHR1 (0.59) | CRHR1 | |
| SCHEMBL5843491 | 0.64 | CRHR1 (0.40) | CRHR1 | |
| SCHEMBL5843094 | 0.64 | CRHR1 (0.48) | CRHR1 | |
| SCHEMBL5787105 | 0.64 | CRHR1 (0.50) | CRHR1 | |
| SCHEMBL5844423 | 0.64 | CRHR1 (0.41) | CRHR1 | |
| SCHEMBL5842985 | 0.64 | CRHR1 (0.41) | CRHR1 | |
| SCHEMBL5844195 | 0.63 | CRHR1 (0.49) | LMNAGAACRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6844351-B1 | Corticotropin releasing factor antagonists | PFIZER INC. (US) | 2005-01-18 | — | — | US | disclosed |