Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.33 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6430842 | 0.82 | LMNA (0.39) | LMNAGAACRHR1RAPGEF4 | |
| SCHEMBL6428343 | 0.74 | LMNA (0.35) | LMNAGAACRHR1RAPGEF4 | |
| SCHEMBL5845086 | 0.70 | CRHR1 (0.46) | CRHR1 | |
| SCHEMBL6428205 | 0.65 | CRHR1 (0.41) | CRHR1 | |
| SCHEMBL6428372 | 0.65 | CRHR1 (0.43) | CRHR1 | |
| SCHEMBL6430481 | 0.60 | LMNA (0.39) | LMNAGAACRHR1RAPGEF4 | |
| SCHEMBL5600278 | 0.58 | CRHR1 (0.59) | CRHR1 | |
| SCHEMBL7013499 | 0.58 | CRHR1 (0.44) | LMNAGAACRHR1 | |
| SCHEMBL5843491 | 0.58 | CRHR1 (0.40) | CRHR1 | |
| SCHEMBL5843094 | 0.58 | CRHR1 (0.48) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6844351-B1 | Corticotropin releasing factor antagonists | PFIZER INC. (US) | 2005-01-18 | — | — | US | disclosed |