Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | HCK | P08631 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.39 |
| ▸ | PRKDC | P78527 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6428641 | 1.00 | HTR6 (0.47) | HTR6KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL14811046 | 0.75 | HTR6 (0.43) | HTR6KDM4EALDH1A1MAPTCHRNA7 | |
| SCHEMBL6426765 | 0.73 | MAPK11 (0.43) | KDM4EALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL6426242 | 0.73 | MAPK11 (0.43) | KDM4EALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL8706306 | 0.72 | HTR6 (0.38) | HTR6 | |
| SCHEMBL7831584 | 0.72 | SLC6A4 (0.51) | HTR6OPRM1HTR1AAHR | |
| SCHEMBL7007800 | 0.70 | SLC6A4 (0.59) | — | |
| SCHEMBL7007803 | 0.70 | SLC6A4 (0.59) | — | |
| SCHEMBL7010593 | 0.70 | HTR1D (0.61) | HTR1DBRD4MPO | |
| SCHEMBL7006155 | 0.69 | HTR1D (0.63) | HTR6HTR1DL3MBTL1KCNH2MPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6897215-B1 | Compounds having 5-HT6 receptor antagonist activity | NPS ALLELIX CORP. (CA) | 2005-05-24 | — | — | US | disclosed |
| WO-2001032660-A1 | COMPOUNDS HAVING 5-HT6 RECEPTOR ANTAGONIST ACTIVITY | NPS ALLELIX CORP. (US) | 2001-05-10 | — | — | WO | disclosed |