Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5843931 | 0.88 | CRHR1 (0.38) | CRHR1 | |
| SCHEMBL5843954 | 0.81 | CRHR1 (0.41) | CRHR1MEN1LMNAMAPTKMT2A | |
| SCHEMBL5845230 | 0.81 | CRHR1 (0.37) | CRHR1 | |
| SCHEMBL27312762 | 0.81 | MAPT (0.33) | CRHR1MEN1LMNAMAPTKMT2A | |
| SCHEMBL5845410 | 0.79 | MAPT (0.36) | CRHR1MEN1LMNAMAPTKMT2A | |
| SCHEMBL27315800 | 0.78 | MAPT (0.31) | CRHR1MAPT | |
| SCHEMBL5845130 | 0.75 | CRHR1 (0.46) | CRHR1 | |
| SCHEMBL5844265 | 0.72 | CRHR1 (0.42) | CRHR1 | |
| SCHEMBL27584910 | 0.69 | CYP19A1 (0.38) | CRHR1LMNAMAPTKMT2A | |
| SCHEMBL5843758 | 0.69 | LMNA (0.43) | CRHR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6844351-B1 | Corticotropin releasing factor antagonists | PFIZER INC. (US) | 2005-01-18 | — | — | US | disclosed |
| US-5962479-A | Corticotropin releasing factor antagonists | PFIZER INC. (US) | 1999-10-05 | — | — | US | disclosed |