Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 10/20 | 0.77 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.63 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.62 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.62 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.62 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | PTGES | O14684 | 1/20 | 0.62 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.62 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.62 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.62 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.62 |
| ▸ | ALB | P02768 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6429121 | 0.87 | PTGS2 (0.65) | PTGS2PLA2G2APTGS1AKR1C3MEN1 | |
| SCHEMBL2238173 | 0.87 | PTGS2 (1.00) | PTGS2PLA2G2APTGS1AKR1C3MEN1 | |
| SCHEMBL19292039 | 0.79 | PLA2G2A (0.65) | PTGS2PLA2G2A | |
| SCHEMBL10591324 | 0.79 | PLA2G2A (0.65) | PTGS2PLA2G2A | |
| SCHEMBL8606314 | 0.78 | PTGS2 (0.84) | PTGS2PTGS1AKR1C3MEN1LMNA | |
| Indomethacin SCHEMBL28301734 | 0.78 | PTGS2 (0.92) | PTGS2PTGS1AKR1C3MEN1LMNA | |
| SCHEMBL9654237 | 0.77 | PTGS2 (0.84) | PTGS2PTGS1AKR1C3MEN1LMNA | |
| SCHEMBL17385243 | 0.77 | PTGS2 (0.84) | PTGS2PLA2G2APTGS1AKR1C3MEN1 | |
| SCHEMBL15774078 | 0.76 | PTGS2 (0.84) | PTGS2PTGS1AKR1C3MEN1LMNA | |
| SCHEMBL5534201 | 0.76 | PTGS2 (0.84) | PTGS2PTGS1AKR1C3MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050002859-A1 | COX-2-targeted imaging agents | VANDERBILT UNIVERSITY (US) | 2005-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050002859-A1 | COX-2-targeted imaging agents | PTGS2, PTGES2, PTGER2 | PTGS2 1/4885PLA2G2A 50/4885PTGS1 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.