Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 1.00 |
| ▸ | HPGD | P15428 | 7/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.71 |
| ▸ | MEN1 | O00255 | 3/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.68 |
| ▸ | RAB9A | P51151 | 4/20 | 0.68 |
| ▸ | MAPT | P10636 | 3/20 | 0.68 |
| ▸ | NPC1 | O15118 | 3/20 | 0.68 |
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
| ▸ | PKM | P14618 | 1/20 | 0.68 |
| ▸ | THRB | P10828 | 1/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL430687 | 0.81 | HPGD (1.00) | ALDH1A1HPGDKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL7159563 | 0.80 | ALDH1A1 (1.00) | ALDH1A1HPGDKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL6427573 | 0.79 | LMNA (0.73) | ALDH1A1HPGDKMT2AMEN1RAB9A | |
| SCHEMBL8790687 | 0.78 | ALDH1A1 (0.67) | ALDH1A1HPGDKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL1448060 | 0.78 | ALDH1A1 (0.67) | ALDH1A1HPGDKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL11761142 | 0.78 | NPC1 (0.82) | ALDH1A1HPGDKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL9416606 | 0.78 | NPC1 (0.82) | ALDH1A1HPGDKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL24426002 | 0.78 | ALDH1A1 (0.76) | ALDH1A1HPGDKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL3215052 | 0.77 | ALDH1A1 (0.75) | ALDH1A1HPGDKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL26644596 | 0.77 | ALDH1A1 (0.68) | ALDH1A1HPGDKMT2AMEN1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050222408-A1 | Heterocyclic amides with anti-tuberculosis activity | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION | 2005-10-06 | — | — | US | disclosed |
| US-20050026968-A1 | Heterocyclic amides with anti-tuberculosis activity | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION | 2005-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050222408-A1 | Heterocyclic amides with anti-tuberculosis activity | TST, KAT5, NDUFS5 | ALDH1A1 2116/4885HPGD 660/4885KMT2A 2545/4885 |
| US-20050026968-A1 | Heterocyclic amides with anti-tuberculosis activity | TST, KAT5, HDAC5 | ALDH1A1 2819/4885HPGD 632/4885KMT2A 2476/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.