SCHEMBL6429705

SCHEMBL6429705

CC(=O)C(C)(CN1CCN(CCO)CC1)SN=O

nearest known ligand 0.33

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.33
LMNA P02545 2/20 0.33
POLB P06746 2/20 0.33
HPGD P15428 2/20 0.33
GAA P10253 1/20 0.33
THRB P10828 1/20 0.33
TSHR P16473 1/20 0.33
KDM4E B2RXH2 1/20 0.33
HTT P42858 2/20 0.32
KMT2A Q03164 1/20 0.32
HSD11B1 P28845 1/20 0.31
ALOX15 P16050 1/20 0.31
ALOX12 P18054 1/20 0.31
HSD17B10 Q99714 1/20 0.31
APOBEC3G Q9HC16 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6431806 0.81 ALDH1A1 (0.36) ALDH1A1LMNAPOLBHPGDGAA
SCHEMBL6947779 0.72 TSHR (0.39) ALDH1A1LMNAPOLBHPGDGAA
SCHEMBL12156215 0.68 ALDH1A1 (0.46) ALDH1A1LMNAPOLBHPGDGAA
Acetic Acid SCHEMBL137819 0.68 ALDH1A1 (0.50) ALDH1A1LMNAPOLBTSHRKDM4E
Acetic Acid SCHEMBL9328243 0.68 ALDH1A1 (0.50) ALDH1A1LMNAPOLBTSHRKDM4E
SCHEMBL6431570 0.68 HTR1A (0.40) ALDH1A1LMNAKDM4E
SCHEMBL22996262 0.65 ALDH1A1 (0.43) ALDH1A1LMNAPOLBHPGDGAA
SCHEMBL10465693 0.65 ALDH1A1 (0.43) ALDH1A1LMNAPOLBHPGDGAA
SCHEMBL5677281 0.65 ALDH1A1 (0.43) ALDH1A1LMNAPOLBHPGDGAA
SCHEMBL2321115 0.65 ALDH1A1 (0.39) ALDH1A1LMNAPOLBHPGDGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1126838-A4 NITROSATED AND NITROSYLATED NONSTEROIDAL ANTIINFLAMMATORY COMPOUNDS, COMPOSITIONS AND METHODS OF USE NITROMED INC (US) 2005-02-16 EP disclosed
EP-1126838-A1 NITROSATED AND NITROSYLATED NONSTEROIDAL ANTIINFLAMMATORY COMPOUNDS, COMPOSITIONS AND METHODS OF USE Nitromed, Inc. (US) 2001-08-29 EP disclosed
WO-2000025776-A1 NITROSATED AND NITROSYLATED NONSTEROIDAL ANTIINFLAMMATORY COMPOUNDS, COMPOSITIONS AND METHODS OF USE NITROMED, INC. (US) 2000-05-11 WO disclosed