Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Tyrosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 3/20 | 0.46 |
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.44 |
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.63 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.53 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.53 |
| ▸ | GSR | P00390 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | ALPI | P09923 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | XIAP | P98170 | 1/20 | 0.46 |
| ▸ | LNPEP | Q9UIQ6 | 2/20 | 0.46 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tyrosine SCHEMBL5666710 | 1.00 | SLC7A5 (0.63) | SLC7A5ITGB3ITGA2BGSRTHRB | |
| Tyrosine SCHEMBL28735029 | 0.96 | SLC7A5 (0.58) | SLC7A5ITGB3ITGA2BGSRTHRB | |
| Tyrosine SCHEMBL3497595 | 0.95 | SLC7A5 (0.57) | SLC7A5ITGB3ITGA2BGSRTHRB | |
| Tyrosine SCHEMBL21925058 | 0.93 | SLC7A5 (0.73) | SLC7A5ITGB3ITGA2BGSRTHRB | |
| Tyrosine SCHEMBL3485478 | 0.93 | SLC7A5 (0.73) | SLC7A5ITGB3ITGA2BGSRTHRB | |
| Tyrosine SCHEMBL3303402 | 0.93 | SLC7A5 (0.73) | SLC7A5ITGB3ITGA2BGSRTHRB | |
| Tyrosine SCHEMBL571284 | 0.93 | SLC7A5 (0.73) | SLC7A5ITGB3ITGA2BGSRTHRB | |
| Tyrosine SCHEMBL27709284 | 0.92 | SLC7A5 (0.71) | SLC7A5ITGB3ITGA2BGSRTHRB | |
| Tyrosine SCHEMBL22207546 | 0.89 | SLC7A5 (0.67) | SLC7A5ITGB3ITGA2BGSRTHRB | |
| Tyrosine SCHEMBL22654492 | 0.89 | SLC7A5 (0.67) | SLC7A5ITGB3ITGA2BGSRTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1309552-A4 | COMPOUNDS AND INHIBITORS OF PHOSPHOLIPASES | UNIV QUEENSLAND (AU) | 2005-07-20 | — | — | EP | disclosed |
| EP-1309552-A1 | COMPOUNDS AND INHIBITORS OF PHOSPHOLIPASES | THE UNIVERSITY OF QUEENSLAND (AU) | 2003-05-14 | — | — | EP | disclosed |
| WO-2002008189-A1 | COMPOUNDS AND INHIBITORS OF PHOSPHOLIPASES | THE UNIVERSITY OF QUEENSLAND (AU) | 2002-01-31 | — | — | WO | disclosed |