Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Tyrosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 2/20 | 0.42 |
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.41 |
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.57 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.49 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | GSR | P00390 | 1/20 | 0.48 |
| ▸ | LNPEP | Q9UIQ6 | 2/20 | 0.43 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.43 |
| ▸ | ALPI | P09923 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | XIAP | P98170 | 1/20 | 0.42 |
| ▸ | PCNA | P12004 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tyrosine SCHEMBL5666710 | 0.95 | SLC7A5 (0.63) | SLC7A5ITGB3ITGA2BTHRBGSR | |
| Tyrosine SCHEMBL6429835 | 0.95 | SLC7A5 (0.63) | SLC7A5ITGB3ITGA2BTHRBGSR | |
| Tyrosine SCHEMBL1921853 | 0.94 | SLC7A5 (0.65) | SLC7A5ITGB3ITGA2BTHRBGSR | |
| Tyrosine SCHEMBL530008 | 0.94 | SLC7A5 (0.65) | SLC7A5ITGB3ITGA2BTHRBGSR | |
| Tyrosine SCHEMBL3513723 | 0.94 | SLC7A5 (0.65) | SLC7A5ITGB3ITGA2BTHRBGSR | |
| Tyrosine SCHEMBL1920944 | 0.94 | SLC7A5 (0.65) | SLC7A5ITGB3ITGA2BTHRBGSR | |
| Tyrosine SCHEMBL28735029 | 0.92 | SLC7A5 (0.58) | SLC7A5ITGB3ITGA2BTHRBGSR | |
| Tyrosine SCHEMBL9341964 | 0.90 | SLC7A5 (0.60) | SLC7A5ITGB3ITGA2BTHRBGSR | |
| Tyrosine SCHEMBL28159330 | 0.89 | SLC7A5 (0.58) | SLC7A5ITGB3ITGA2BTHRBGSR | |
| Tyrosine SCHEMBL571284 | 0.89 | SLC7A5 (0.73) | SLC7A5ITGB3ITGA2BTHRBGSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100143364-A1 | Chimeric Antibodies, Compositions and Methods for Treating Cocaine-Related Disorders | VYBION, INC. (US) | 2010-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100143364-A1 | Chimeric Antibodies, Compositions and Methods for Treating Cocaine-Related Disorders | CES2, CHRNA5, CHRNA3 | PTGS1 4848/4885PTGS2 4844/4885SLC7A5 4325/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.