Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.53 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | HPGDS | O60760 | 2/20 | 0.48 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.46 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.44 |
| ▸ | CTSG | P08311 | 1/20 | 0.44 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.44 |
| ▸ | CMA1 | P23946 | 1/20 | 0.44 |
| ▸ | EEF2K | O00418 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | F2R | P25116 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1386996 | 0.84 | LMNA (0.79) | LMNAGAAALDH1A1HPGDSTSHR | |
| Formaldehyde SCHEMBL27761965 | 0.81 | LMNA (0.73) | LMNAGAAALDH1A1HPGDSTSHR | |
| Ethylene SCHEMBL21647328 | 0.81 | LMNA (0.73) | LMNAGAAALDH1A1HPGDSTSHR | |
| SCHEMBL3461364 | 0.80 | LMNA (0.72) | LMNAGAAALDH1A1HPGDSTSHR | |
| SCHEMBL20529655 | 0.78 | MEN1 (0.49) | LMNACYP2D6CYP2C9SLC6A9SLC6A5 | |
| SCHEMBL22408310 | 0.78 | LMNA (1.00) | LMNASLC6A9GAAHSD17B2ALDH1A1 | |
| SCHEMBL18010560 | 0.78 | LMNA (0.70) | LMNASLC6A9SLC6A5GAAHSD17B2 | |
| Hydrochloric Acid SCHEMBL28055613 | 0.77 | LMNA (0.97) | LMNASLC6A9GAAHSD17B2ALDH1A1 | |
| SCHEMBL6168003 | 0.74 | TSHR (0.48) | LMNACYP2D6CYP2C9SLC6A9SLC6A5 | |
| SCHEMBL29181717 | 0.73 | LMNA (0.62) | LMNAGAAALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050032789-A1 | Novel compounds useful in pain management | ASTRAZENECA CANADA INC. | 2005-02-10 | — | — | US | disclosed |
| EP-1089965-B1 | Urea derivatives for pain management | ASTRAZENECA AB (SE) | 2004-09-15 | — | — | EP | disclosed |
| US-6777561-B1 | MANAGEMENT OF PAIN; PHENYL-UREA COMPOUNDS | ASTRAZENECA CANADA INC. (CA) | 2004-08-17 | — | — | US | disclosed |
| EP-1089965-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2001-04-11 | — | — | EP | disclosed |
| WO-1999067204-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 1999-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050032789-A1 | Novel compounds useful in pain management | OPRL1, OPRK1, OPRM1 | LMNA 4274/4885CYP2D6 599/4885CYP2C9 2082/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.