Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.35 |
| ▸ | TGM2 | P21980 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7108511 | 0.90 | ALDH1A1 (0.43) | EPHX2LMNAALDH1A1MAPK1KMT2A | |
| SCHEMBL2404702 | 0.86 | EPHX2 (0.41) | EPHX2LMNAALDH1A1L3MBTL1MAPK1 | |
| SCHEMBL6413066 | 0.83 | EPHX2 (0.43) | EPHX2LMNAALDH1A1L3MBTL1MAPK1 | |
| SCHEMBL6414411 | 0.82 | LMNA (0.42) | EPHX2LMNAALDH1A1L3MBTL1MAPK1 | |
| SCHEMBL6410956 | 0.79 | LMNA (0.41) | LMNAALDH1A1L3MBTL1MAPK1KMT2A | |
| SCHEMBL6411079 | 0.78 | LMNA (0.44) | LMNAALDH1A1L3MBTL1MAPK1KMT2A | |
| SCHEMBL6409435 | 0.78 | LMNA (0.38) | LMNAALDH1A1L3MBTL1MAPK1KMT2A | |
| SCHEMBL6414303 | 0.78 | CYP3A4 (0.41) | LMNAALDH1A1MAPK1KMT2AMEN1 | |
| SCHEMBL6411568 | 0.76 | MAPT (0.50) | LMNAALDH1A1MAPK1KMT2AMEN1 | |
| SCHEMBL6410801 | 0.76 | KMT2A (0.48) | LMNAALDH1A1L3MBTL1MAPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1401841-B1 | SUBSTITUTED 1-OXA-2,8-DIAZA-SPIRO 4,5]DEC-2-ENE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF PAIN | GRUENENTHAL GMBH (DE) | 2005-08-24 | — | — | EP | claimed |
| EP-1401841-B1 | SUBSTITUTED 1-OXA-2,8-DIAZA-SPIRO 4,5]DEC-2-ENE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF PAIN | GRUENENTHAL GMBH (DE) | 2005-08-24 | — | — | EP | disclosed |