SCHEMBL7108511

SCHEMBL7108511

O=C(NCc1cccc2ccccc12)OC1=NOC2(CCN(S(=O)(=O)c3ccc(Cl)s3)CC2)C1.O=C(NCc1cccs1)OC1=NOC2(CCN(S(=O)(=O)c3ccc(Cl)cc3)CC2)C1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.43
PKM P14618 2/20 0.43
LMNA P02545 5/20 0.38
SMN1; SMN2 Q16637 3/20 0.38
TP53 P04637 1/20 0.38
GAA P10253 3/20 0.36
TSHR P16473 3/20 0.36
ALOX15 P16050 2/20 0.36
HSD17B10 Q99714 1/20 0.36
EPHX2 P34913 1/20 0.36
POLB P06746 3/20 0.36
MAPT P10636 2/20 0.36
ATM Q13315 1/20 0.36
MEN1 O00255 2/20 0.35
KMT2A Q03164 2/20 0.35
MAPK1 P28482 2/20 0.35
HTT P42858 2/20 0.35
NPSR1 Q6W5P4 2/20 0.35
USP2 O75604 1/20 0.35
TGM2 P21980 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6430541 0.90 EPHX2 (0.40) ALDH1A1PKMLMNASMN1; SMN2GAA
SCHEMBL6409896 0.86 ALDH1A1 (0.56) ALDH1A1PKMLMNASMN1; SMN2TP53
SCHEMBL2404702 0.78 EPHX2 (0.41) ALDH1A1PKMLMNASMN1; SMN2GAA
SCHEMBL6409948 0.78 KDM4E (0.47) ALDH1A1PKMLMNASMN1; SMN2TP53
SCHEMBL6410088 0.77 KMT2A (0.44) ALDH1A1PKMLMNASMN1; SMN2TP53
SCHEMBL6413066 0.76 EPHX2 (0.43) ALDH1A1PKMLMNASMN1; SMN2GAA
SCHEMBL6411568 0.74 MAPT (0.50) ALDH1A1PKMLMNASMN1; SMN2GAA
SCHEMBL6431092 0.74 AVPR1A (0.41) ALDH1A1LMNASMN1; SMN2POLBMAPK1
SCHEMBL6414411 0.74 LMNA (0.42) ALDH1A1PKMLMNASMN1; SMN2GAA
SCHEMBL2400969 0.74 ALDH1A1 (0.58) ALDH1A1PKMLMNASMN1; SMN2TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1401841-A1 SUBSTITUTED 1-OXA-2,8-DIAZA-SPIRO 4,5]DEC-2-ENE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF PAIN Grünenthal GmbH (DE) 2004-03-31 EP claimed
WO-2003000699-A1 SUBSTITUTED 1-OXA-2,8-DIAZA-SPIRO[4,5]DEC-2-ENE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF PAIN Grünenthal GmbH (DE) 2003-01-03 WO claimed
EP-1401841-A1 SUBSTITUTED 1-OXA-2,8-DIAZA-SPIRO 4,5]DEC-2-ENE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF PAIN Grünenthal GmbH (DE) 2004-03-31 EP disclosed
WO-2003000699-A1 SUBSTITUTED 1-OXA-2,8-DIAZA-SPIRO[4,5]DEC-2-ENE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF PAIN Grünenthal GmbH (DE) 2003-01-03 WO disclosed