Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 4/20 | 0.52 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6430253 | 0.80 | CRHR1 (0.42) | CRHR1 | |
| SCHEMBL6428408 | 0.77 | CRHR1 (0.38) | CRHR1 | |
| SCHEMBL8344779 | 0.74 | CRHR1 (0.47) | CRHR1 | |
| SCHEMBL5844150 | 0.74 | CRHR1 (0.77) | CRHR1 | |
| SCHEMBL5845345 | 0.72 | CRHR1 (0.55) | CRHR1 | |
| SCHEMBL6428379 | 0.70 | CRHR1 (0.42) | CRHR1 | |
| SCHEMBL6428447 | 0.69 | CRHR1 (0.52) | CRHR1 | |
| SCHEMBL123421 | 0.69 | CRHR1 (1.00) | CRHR1 | |
| SCHEMBL30397878 | 0.69 | CRHR1 (1.00) | CRHR1 | |
| SCHEMBL5844689 | 0.68 | CRHR1 (0.75) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6844351-B1 | Corticotropin releasing factor antagonists | PFIZER INC. (US) | 2005-01-18 | — | — | US | disclosed |