Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.40 |
| ▸ | FPR2 | P25090 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | HTR6 | P50406 | 2/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | HTR1B | P28222 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6694235 | 1.00 | MEN1 (0.43) | MEN1KMT2ATRPV4FPR2SLC6A2 | |
| SCHEMBL6430991 | 1.00 | MEN1 (0.43) | MEN1KMT2ATRPV4FPR2SLC6A2 | |
| SCHEMBL1737826 | 0.88 | KMT2A (0.42) | MEN1KMT2AHTR1AHTR2ADRD2 | |
| SCHEMBL1737824 | 0.88 | KMT2A (0.42) | MEN1KMT2AHTR1AHTR2ADRD2 | |
| SCHEMBL6431233 | 0.88 | KMT2A (0.48) | MEN1KMT2AADRA1DADRA1AADRA1B | |
| SCHEMBL6431229 | 0.88 | KMT2A (0.48) | MEN1KMT2AADRA1DADRA1AADRA1B | |
| SCHEMBL6431248 | 0.87 | KMT2A (0.46) | MEN1KMT2AADRA1DADRA1AADRA1B | |
| SCHEMBL6431251 | 0.87 | KMT2A (0.46) | MEN1KMT2AADRA1DADRA1AADRA1B | |
| SCHEMBL6431240 | 0.86 | MEN1 (0.45) | MEN1KMT2AHTR1AHTR2ADRD2 | |
| SCHEMBL6431236 | 0.86 | MEN1 (0.45) | MEN1KMT2AHTR1AHTR2ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0894085-B1 | BENZYL(IDENE)-LACTAM DERIVATIVES, THEIR PREPARATION AND THEIR USE AS SELECTIVE (ANT)AGONISTS OF 5-HT1A- AND/OR 5-HT1D RECEPTORS | PFIZER (US) | 2005-08-17 | — | — | EP | claimed |
| US-20030027812-A1 | Benzyl(idene)-lactam derivatives, their preperation and their use as selective (ant)agonists of 5-HT1A- and/or 5-HT1D receptors | PFIZER INC. | 2003-02-06 | — | — | US | claimed |
| US-6462048-B2 | 3-(2-(4-METHYLPIPERAZIN-1-YL)-BENZYLIDENE)-1,3-DIHYDRO-INDOL-2-ONE FOR EXAMPLE; USEFUL AS PSYCHOTHERAPEUTIC AGENTS | PFIZER INC. | 2002-10-08 | — | — | US | claimed |
| US-20020028821-A1 | BENZYL(IDENE)-LACTAM DERIVATIVES, THEIR PREPARATION AND THEIR USE AS SELECTIVE (ANT)AGONISTS OF 5-HT1A- AND/OR 5-HT1D RECEPTORS | HOWARD HARRY R (US) | 2002-03-07 | — | — | US | claimed |
| WO-2020183011-A1 | HTR1D INHIBITORS AND USES THEREOF IN THE TREATMENT OF CANCER | INSTITUT CURIE (FR) | 2020-09-17 | — | — | WO | disclosed |
| EP-0894085-B1 | BENZYL(IDENE)-LACTAM DERIVATIVES, THEIR PREPARATION AND THEIR USE AS SELECTIVE (ANT)AGONISTS OF 5-HT1A- AND/OR 5-HT1D RECEPTORS | PFIZER (US) | 2005-08-17 | — | — | EP | disclosed |
| US-6924289-B2 | Benzyl(Idene)-lactam derivatives, their preparation and their use as selective (ANT) agonists of 5-HT1A- and/or 5-HT1D receptors | PFIZER INC (US) | 2005-08-02 | — | — | US | disclosed |
| EP-1113015-B1 | Optically active 3-((2-piperazinyl-phenyl)methyl)-1-(4-(trifluoromethyl)-phenyl)-2-pyrrolidinone compounds as 5-HT1D receptor selective antagonists | PFIZER PROD INC (US) | 2004-09-15 | — | — | EP | disclosed |
| CN-1128788-C | Benzyl(idene)-lactam derivatives, their prepn. and their use as selective (ant) agaonists of 5-ht1A-and/or 5-ht1D receptors | PFIZER (US) | 2003-11-26 | — | — | CN | disclosed |
| US-20030083337-A1 | Optically active 3-[(2-piperazinylphenyl)methyl]-1-[4-(trifluoromethyl)phenyl]-2-pyrrolidinone compounds as 5-HT1D receptor selective antagonists | PFIZER PRODUCTS, INC. | 2003-05-01 | — | — | US | disclosed |
| US-20030027812-A1 | Benzyl(idene)-lactam derivatives, their preperation and their use as selective (ant)agonists of 5-HT1A- and/or 5-HT1D receptors | PFIZER INC. | 2003-02-06 | — | — | US | disclosed |
| US-6462048-B2 | 3-(2-(4-METHYLPIPERAZIN-1-YL)-BENZYLIDENE)-1,3-DIHYDRO-INDOL-2-ONE FOR EXAMPLE; USEFUL AS PSYCHOTHERAPEUTIC AGENTS | PFIZER INC. | 2002-10-08 | — | — | US | disclosed |
| US-20020028821-A1 | BENZYL(IDENE)-LACTAM DERIVATIVES, THEIR PREPARATION AND THEIR USE AS SELECTIVE (ANT)AGONISTS OF 5-HT1A- AND/OR 5-HT1D RECEPTORS | HOWARD HARRY R (US) | 2002-03-07 | — | — | US | disclosed |
| US-20010039280-A1 | Optically active 3-[(2-Piperazinylphenyl)methyl]-1-[4-(trifluoromethyl)phenyl]-2-pyrrolidinone compounds as 5-HT 1D receptor selective antagonists | PFIZER PRODUCTS INC. | 2001-11-08 | — | — | US | disclosed |
| EP-1113015-A1 | Optically active 3-((2-piperazinyl-phenyl)methyl)-1-(4-(trifluoromethyl)-phenyl)-2-pyrrolidinone compounds as 5-HT1D receptor selective antagonists | Pfizer Products Inc. (US) | 2001-07-04 | — | — | EP | disclosed |
| CN-1214043-A | Benzyl(idene)-lactam derivatives, their prepn. and their use as selective (ant) agaonists of 5-ht1A-and/or 5-ht1D receptors | PFIZER (US) | 1999-04-14 | — | — | CN | disclosed |
| EP-0894085-A1 | BENZYL(IDENE)-LACTAM DERIVATIVES, THEIR PREPARATION AND THEIR USE AS SELECTIVE (ANT)AGONISTS OF 5-HT1A- AND/OR 5-HT1D RECEPTORS | PFIZER INC. (US) | 1999-02-03 | — | — | EP | disclosed |
| WO-1997036867-A1 | BENZYL(IDENE)-LACTAM DERIVATIVES, THEIR PREPARATION AND THEIR USE AS SELECTIVE (ANT)AGONISTS OF 5-HT1A- AND/OR 5-HT1D RECEPTORS | PFIZER INC. (US) | 1997-10-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010039280-A1 | Optically active 3-[(2-Piperazinylphenyl)methyl]-1-[4-(trifluoromethyl)phenyl]-2-pyrrolidinone compounds as 5-HT 1D receptor selective antagonists | HTR1D, HTR1A, HTR5A | MEN1 3544/4885KMT2A 2127/4885TRPV4 264/4885 |
| US-20030083337-A1 | Optically active 3-[(2-piperazinylphenyl)methyl]-1-[4-(trifluoromethyl)phenyl]-2-pyrrolidinone compounds as 5-HT1D receptor selective antagonists | HTR1D, HTR1A, HTR3D | MEN1 2846/4885KMT2A 2317/4885TRPV4 227/4885 |
| US-20020028821-A1 | BENZYL(IDENE)-LACTAM DERIVATIVES, THEIR PREPARATION AND THEIR USE AS SELECTIVE (ANT)AGONISTS OF 5-HT1A- AND/OR 5-HT1D RECEPTORS | HTR1E, HTR1D, HTR1A | MEN1 1027/4885KMT2A 3996/4885TRPV4 1767/4885 |
| US-20030027812-A1 | Benzyl(idene)-lactam derivatives, their preperation and their use as selective (ant)agonists of 5-HT1A- and/or 5-HT1D receptors | HTR1A, HTR1E, HTR1D | MEN1 423/4885KMT2A 2821/4885TRPV4 1951/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.