SCHEMBL6431934

SCHEMBL6431934

Cc1nc(N2CCN(S(=O)(=O)c3ccc(CNC(=O)c4ccc(Cl)cc4)s3)CC2)c(C(=O)O)cc1C#N

nearest known ligand 0.47

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MAPK9 P45984 1/20 0.47
MAPK10 P53779 1/20 0.47
MEN1 O00255 1/20 0.45
KMT2A Q03164 1/20 0.45
P2RY12 Q9H244 10/20 0.41
BCL2 P10415 1/20 0.40
BCL2L1 Q07817 1/20 0.40
DRD2 P14416 1/20 0.38
DRD4 P21917 1/20 0.38
DRD3 P35462 1/20 0.38
MAPT P10636 3/20 0.37
LMNA P02545 1/20 0.36
POLB P06746 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
RXFP1 Q9HBX9 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2427324 0.91 P2RY12 (0.51) MAPK9MAPK10MEN1KMT2AP2RY12
SCHEMBL7896074 0.80 MAPK9 (0.48) MAPK9MAPK10MEN1KMT2ABCL2
SCHEMBL3479929 0.80 DRD2 (0.60) MAPK9MAPK10MEN1KMT2ABCL2
SCHEMBL3479828 0.80 MAPK9 (0.52) MAPK9MAPK10MEN1KMT2ABCL2
SCHEMBL2423054 0.77 MAPK9 (0.59) MAPK9MAPK10MEN1KMT2ABCL2
SCHEMBL3480233 0.76 MAPK9 (0.55) MAPK9MAPK10MEN1KMT2ABCL2
SCHEMBL2424858 0.76 MAPK9 (0.61) MAPK9MAPK10MEN1KMT2ABCL2
SCHEMBL2425191 0.76 MAPK9 (0.51) MAPK9MAPK10MEN1KMT2ABCL2
Benzamide SCHEMBL7444468 0.76 MAPK9 (0.50) MAPK9MAPK10MEN1KMT2ABCL2
SCHEMBL3479858 0.76 MAPK9 (0.47) MAPK9MAPK10MEN1KMT2ABCL2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1218374-B1 PHARMACEUTICALLY ACTIVE SULFONAMIDE DERIVATIVES APPLIED RESEARCH SYSTEMS (AN) 2005-11-16 EP claimed