SCHEMBL6432006

SCHEMBL6432006

OCCCCCCCCCCCCc1cccc2nc3ccccc3cc12

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.46
GLA P06280 4/20 0.46
HPGD P15428 3/20 0.46
POLB P06746 3/20 0.46
KDM4E B2RXH2 3/20 0.46
GAA P10253 3/20 0.46
LMNA P02545 2/20 0.46
RAB9A P51151 2/20 0.46
NPC1 O15118 1/20 0.46
PTBP1 P26599 1/20 0.46
KMT2A Q03164 1/20 0.46
RCE1 Q9Y256 1/20 0.46
TLR8 Q9NR97 11/20 0.45
RAD52 P43351 2/20 0.42
MAPT P10636 2/20 0.41
ACHE P22303 1/20 0.41
USP2 O75604 1/20 0.40
CYP3A4 P08684 1/20 0.40
CASP1 P29466 1/20 0.40
CASP7 P55210 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29629266 0.92 ALDH1A1 (0.53) ALDH1A1GLAHPGDPOLBKDM4E
SCHEMBL28491074 0.92 ALDH1A1 (0.53) ALDH1A1GLAHPGDPOLBKDM4E
SCHEMBL30434810 0.92 ALDH1A1 (0.53) ALDH1A1GLAHPGDPOLBKDM4E
SCHEMBL195797 0.92 ALDH1A1 (0.53) ALDH1A1GLAHPGDPOLBKDM4E
SCHEMBL30376957 0.87 ALDH1A1 (0.51) ALDH1A1GLAHPGDPOLBKDM4E
SCHEMBL1484136 0.87 ALDH1A1 (0.51) ALDH1A1GLAHPGDPOLBKDM4E
SCHEMBL22497413 0.87 ALDH1A1 (0.55) ALDH1A1GLAHPGDPOLBKDM4E
SCHEMBL20571255 0.86 TLR8 (0.49) ALDH1A1GLAHPGDPOLBKDM4E
SCHEMBL21551636 0.85 TLR8 (0.61) ALDH1A1GLAHPGDPOLBKDM4E
SCHEMBL8003645 0.85 TLR8 (0.61) ALDH1A1GLAHPGDPOLBKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1304572-C Modified antisense nucleotides complementary to section of human Ha-Ras gene HOECHST MARION & ROUSSEL DEUTS (DE) 2007-03-14 CN disclosed
US-20050020523-A1 Modified antisense nucleotides complementary to a section of the human haras gene AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2005-01-27 US disclosed
US-6723706-B2 OLIGONUCLEOTIDE FOR USE AS ANTIPROLIFERATIVE AGENT AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2004-04-20 US disclosed
US-20030064514-A1 MODIFIED ANTISENSE NUCLEOTIDES COMPLEMENTARY TO A SECTION OF THE HUMAN HA-RAS GENE HOECHST MARION ROUSSEL DEUTSCHLAND GMBH 2003-04-03 US disclosed
CN-1255164-A Modified antisense nucleotides complementary to human Ha-ras gene segments HOECHST MARION & ROUSSEL DEUTS (DE) 2000-05-31 CN disclosed
EP-0979273-A1 MODIFIED ANTISENSE NUCLEOTIDES COMPLEMENTARY TO A SECTION OF THE HUMAN Ha-Ras GENE Hoechst Marion Roussel Deutschland GmbH (DE) 2000-02-16 EP disclosed
WO-1998050540-A1 MODIFIED ANTISENSE NUCLEOTIDES COMPLEMENTARY TO A SECTION OF THE HUMAN Ha-Ras GENE HOECHST MARION ROUSSEL DEUTSCHLAND GMBH (DE) 1998-11-12 WO disclosed