SCHEMBL643223

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL642785	0.89	ALDH1A1 (0.46)	GCKSMN1; SMN2ALDH1A1HPGDKCNH2
	SCHEMBL15780545	0.89	HPGD (0.46)	GCKSMN1; SMN2ALDH1A1HPGDKCNH2
	SCHEMBL642434	0.86	GCK (0.60)	GCKSMN1; SMN2TSHRKCNH2LMNA
	SCHEMBL643703	0.86	GCK (0.53)	GCKSMN1; SMN2TSHRLMNAMAPT
	SCHEMBL643367	0.85	GCK (0.45)	GCKSMN1; SMN2TSHRKCNH2LMNA
	SCHEMBL645986	0.85	ALDH1A1 (0.41)	GCKSMN1; SMN2ALDH1A1TSHRLMNA
	SCHEMBL643092	0.85	GCK (0.46)	GCKSMN1; SMN2TSHRKCNH2LMNA
	SCHEMBL2663576	0.84	GCK (0.42)	GCKSMN1; SMN2ALDH1A1HPGDTSHR
	SCHEMBL643412	0.83	MAOB (0.41)	GCKSMN1; SMN2TSHRKCNH2LMNA
	SCHEMBL642344	0.83	GCK (0.41)	GCKSMN1; SMN2TSHRKCNH2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.