Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 8/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 8/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 8/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 8/20 | 0.42 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
| ▸ | AKT2 | P31751 | 3/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL6438144 | 0.88 | DPP7 (0.46) | HRH4HRH3F10 | |
| SCHEMBL16380668 | 0.86 | AKT2 (0.49) | HRH4HRH3OPRM1OPRD1OPRK1 | |
| SCHEMBL6438142 | 0.74 | F10 (0.50) | HRH4HRH3F10MEN1KMT2A | |
| SCHEMBL3391983 | 0.73 | HRH3 (0.55) | HRH4HRH3POLBMEN1MITF | |
| SCHEMBL2554948 | 0.73 | OPRM1 (0.53) | HRH3OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL30771325 | 0.72 | DRD2 (0.43) | HRH3OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL3391932 | 0.71 | POLB (0.49) | HRH4HRH3OPRM1POLBMEN1 | |
| SCHEMBL12346271 | 0.71 | AKT2 (0.47) | HRH3OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL14510672 | 0.71 | KMT2A (0.49) | OPRM1OPRD1OPRK1OPRL1AKT2 | |
| SCHEMBL3317308 | 0.71 | AKT1 (0.49) | AKT2GSK3BMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1042287-B1 | INDOLE DERIVATIVES AS INHIBITORS OF FACTOR XA | AVENTIS PHARMA GMBH (DE) | 2005-04-20 | — | — | EP | disclosed |
| US-6337344-B1 | ANTICOAGULANTS AND ENZYME INHIBITORS FOR CARDIOVASCULAR DISORDERS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-01-08 | — | — | US | disclosed |
| EP-1042287-A1 | INDOLE DERIVATIVES AS INHIBITORS OF FACTOR XA | Aventis Pharma Deutschland GmbH (DE) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999033800-A1 | INDOLE DERIVATIVES AS INHIBITORS OR FACTOR XA | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 1999-07-08 | — | — | WO | disclosed |