Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 6/20 | 0.42 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.42 |
| ▸ | HTR5A | P47898 | 2/20 | 0.40 |
| ▸ | KCNQ3 | O43525 | 5/20 | 0.38 |
| ▸ | KCNQ2 | O43526 | 5/20 | 0.38 |
| ▸ | KCNE1 | P15382 | 5/20 | 0.38 |
| ▸ | KCNQ1 | P51787 | 5/20 | 0.38 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.35 |
| ▸ | PLG | P00747 | 2/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.34 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6433486 | 0.86 | PLAU (0.51) | PLAUNAPRTHTR5APLGPOLB | |
| SCHEMBL13754214 | 0.85 | ALDH1A1 (0.42) | PLAUNAPRTHTR5APLGMAPK1 | |
| SCHEMBL31469865 | 0.78 | NAPRT (0.38) | NAPRTKCNQ3KCNQ2KCNE1KCNQ1 | |
| SCHEMBL8163914 | 0.78 | NAPRT (0.38) | NAPRTKCNQ3KCNQ2KCNE1KCNQ1 | |
| SCHEMBL6437644 | 0.77 | ALDH1A1 (0.53) | MAPK1MEN1NPC1POLBRAB9A | |
| SCHEMBL6438412 | 0.74 | ALDH1A1 (0.38) | PLAUPLGPOLBKMT2A | |
| SCHEMBL2671321 | 0.72 | HIPK2 (0.49) | PLAUNAPRTHIPK2PLGCSNK2A1 | |
| SCHEMBL6332114 | 0.72 | PDE4A (0.47) | NAPRTHIPK2CSNK2A1MAPK1MEN1 | |
| SCHEMBL7403972 | 0.72 | PLAU (0.44) | PLAUMEN1KMT2A | |
| SCHEMBL31185577 | 0.71 | NT5E (0.39) | PLAUPLGMEN1NPC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050026836-A1 | Composition for the treatment of damaged tissue | DACK KEVIN NEIL (GB) | 2005-02-03 | — | — | US | disclosed |
| US-20030199440-A1 | Composition for the treatment of damaged tissue | PFIZER INC. | 2003-10-23 | — | — | US | disclosed |
| EP-1077945-B1 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER (US) | 2003-01-08 | — | — | EP | disclosed |
| EP-1242120-A2 | COMBINATIONS OF GROWTH FACTORS AND I:UPA OR I:MMP FOR THE TREATMENT OF DAMAGED TISSUE | Pfizer Limited (GB) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001049309-A2 | COMBINATIONS OF GROWTH FACTORS AND I: UPA OR I: MMP FOR THE TREATMENT OF DAMAGED TISSUE | PFIZER LIMITED (GB) | 2001-07-12 | — | — | WO | disclosed |
| EP-1077945-A1 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER INC. (US) | 2001-02-28 | — | — | EP | disclosed |
| US-6093731-A | Isoquinolines | PFIZER INC. | 2000-07-25 | — | — | US | disclosed |
| WO-2000005214-A2 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER INC. (US) | 2000-02-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030199440-A1 | Composition for the treatment of damaged tissue | MMP1, SERPINE1, COL14A1 | PLAU 119/4885NAPRT 2404/4885HTR5A 4441/4885 |
| US-20050026836-A1 | Composition for the treatment of damaged tissue | MMP1, SERPINE1, COL14A1 | PLAU 119/4885NAPRT 2404/4885HTR5A 4441/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.