Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | CRHR1 | P34998 | 6/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5844036 | 0.80 | CRHR1 (0.47) | THRBCRHR1 | |
| SCHEMBL5844189 | 0.71 | CRHR1 (0.44) | THRBCRHR1 | |
| SCHEMBL6996284 | 0.70 | CRHR1 (0.44) | THRBCRHR1 | |
| SCHEMBL5843131 | 0.70 | CNR2 (0.39) | THRBCRHR1SRCCNR2TSHR | |
| SCHEMBL5844403 | 0.69 | HPGD (0.44) | CNR2KDM4ETSHRHSD17B10LMNA | |
| SCHEMBL31633893 | 0.67 | THRB (0.45) | THRBPIK3CGSRCCNR2KDM4E | |
| SCHEMBL2055964 | 0.67 | CRHR1 (0.70) | CRHR1 | |
| SCHEMBL3721887 | 0.67 | CRHR1 (0.36) | CRHR1PIK3CGSRCLMNASMN1; SMN2 | |
| SCHEMBL10958304 | 0.64 | SRC (0.54) | THRBPIK3CGSRCMAPK1 | |
| SCHEMBL17247748 | 0.64 | TP53 (0.44) | CRHR1TSHRHSD17B10LMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6844351-B1 | Corticotropin releasing factor antagonists | PFIZER INC. (US) | 2005-01-18 | — | — | US | disclosed |