Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 3/20 | 0.33 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.33 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2055964 | 0.68 | CRHR1 (0.70) | CRHR1 | |
| Ammonia Solution, Strong SCHEMBL6433627 | 0.67 | THRB (0.41) | CRHR1LMNASMN1; SMN2GAAMAPK1 | |
| SCHEMBL17247748 | 0.67 | TP53 (0.44) | CRHR1LMNAMAPK1TP53HTT | |
| SCHEMBL3218068 | 0.65 | CRHR1 (0.53) | CRHR1 | |
| SCHEMBL6996284 | 0.62 | CRHR1 (0.44) | CRHR1 | |
| SCHEMBL19976890 | 0.62 | LMNA (0.39) | LMNASMN1; SMN2GAAMAPK1TAS1R3 | |
| SCHEMBL18593511 | 0.61 | KCNH2 (0.41) | CRHR1LMNASMN1; SMN2GAATP53 | |
| SCHEMBL11857151 | 0.60 | LMNA (0.48) | LMNATP53HTT | |
| SCHEMBL21725453 | 0.60 | LMNA (0.48) | LMNATP53HTT | |
| SCHEMBL13620698 | 0.60 | SMN1; SMN2 (0.46) | LMNASMN1; SMN2GAAMAPK1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2240485-A1 | TRICYCLIC COMPOUNDS HAVING CORTICOTROPIN-RELEASING FACTOR ANTAGONISTIC ACTIVITY AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Takeda Pharmaceutical Company Limited (JP) | 2010-10-20 | — | — | EP | disclosed |
| WO-2009093747-A1 | TRICYCLIC COMPOUNDS HAVING CORTICOTROPIN-RELEASING FACTOR ANTAGONISTIC ACTIVITY AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-07-30 | — | — | WO | disclosed |