Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 16/20 | 0.65 |
| ▸ | ABCC8 | Q09428 | 16/20 | 0.65 |
| ▸ | KCNJ11 | Q14654 | 16/20 | 0.65 |
| ▸ | KCNJ8 | Q15842 | 16/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6910071 | 0.86 | ABCC9 (0.64) | ABCC9ABCC8KCNJ11KCNJ8KDM4E | |
| SCHEMBL6908840 | 0.86 | ABCC9 (0.64) | ABCC9ABCC8KCNJ11KCNJ8KDM4E | |
| SCHEMBL6910007 | 0.86 | ABCC9 (0.64) | ABCC9ABCC8KCNJ11KCNJ8KDM4E | |
| SCHEMBL7236107 | 0.82 | ABCC9 (0.45) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL6431674 | 0.81 | ABCC9 (0.61) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL6432083 | 0.81 | ABCC9 (0.61) | ABCC9ABCC8KCNJ11KCNJ8KDM4E | |
| SCHEMBL6903824 | 0.81 | ABCC9 (0.61) | ABCC9ABCC8KCNJ11KCNJ8KDM4E | |
| SCHEMBL6903919 | 0.81 | ABCC9 (0.61) | ABCC9ABCC8KCNJ11KCNJ8KDM4E | |
| SCHEMBL6432586 | 0.81 | ABCC9 (0.61) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL6435908 | 0.80 | GPR174 (0.56) | ABCC9ABCC8KCNJ11KCNJ8KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1194429-B1 | POTASSIUM CHANNEL OPENERS | ABBOTT LAB (US) | 2005-03-30 | — | — | EP | claimed |
| EP-1194429-A1 | POTASSIUM CHANNEL OPENERS | Abbott Laboratories (US) | 2002-04-10 | — | — | EP | claimed |
| WO-2000078768-A1 | POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2000-12-28 | — | — | WO | claimed |