Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C | P18825 | 9/20 | 0.61 |
| ▸ | ADRA2B | P18089 | 8/20 | 0.61 |
| ▸ | ADRA1A | P35348 | 15/20 | 0.52 |
| ▸ | ADRA1D | P25100 | 13/20 | 0.52 |
| ▸ | ADRA1B | P35368 | 11/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 8/20 | 0.52 |
| ▸ | MAOA | P21397 | 2/20 | 0.52 |
| ▸ | MAOB | P27338 | 2/20 | 0.52 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6366284 | 0.81 | ADRA2C (0.64) | ADRA2CADRA2BADRA1AADRA1DADRA1B | |
| Hydrochloric Acid SCHEMBL6366088 | 0.80 | ADRA2C (0.63) | ADRA2CADRA2BADRA1AADRA1DADRA1B | |
| SCHEMBL6439658 | 0.73 | ADRA1A (0.71) | ADRA2CADRA2BADRA1AADRA1DADRA1B | |
| SCHEMBL6436107 | 0.71 | ADRA1A (0.74) | ADRA2CADRA2BADRA1AADRA1DADRA1B | |
| SCHEMBL11231308 | 0.71 | ADRA2C (1.00) | ADRA2CADRA2BADRA1AADRA1DADRA1B | |
| SCHEMBL6366740 | 0.71 | ADRA1A (0.73) | ADRA2CADRA2BADRA1AADRA1DADRA1B | |
| Hydrochloric Acid SCHEMBL11227435 | 0.70 | ADRA2C (0.97) | ADRA2CADRA2BADRA1AADRA1DADRA1B | |
| Hydrochloric Acid SCHEMBL6367526 | 0.70 | ADRA1A (0.71) | ADRA2CADRA2BADRA1AADRA1DADRA1B | |
| SCHEMBL6367525 | 0.70 | ADRA1A (0.64) | ADRA2CADRA2BADRA1AADRA1DADRA1B | |
| Hydrochloric Acid SCHEMBL9655530 | 0.69 | ADRA2C (0.76) | ADRA2CADRA2BADRA1AADRA1DADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6884801-B1 | Imidazoline derivatives as alpha-1A adrenoceptor ligands | SMITHKLINE BEECHAM CORPORATION (US) | 2005-04-26 | — | — | US | disclosed |
| EP-1175406-A1 | IMIDAZOLINE DERIVATIVES AS ALPHA-1A ADRENOCEPTOR LIGANDS | GLAXO GROUP LIMITED (GB) | 2002-01-30 | — | — | EP | disclosed |
| WO-2000066563-A1 | IMIDAZOLINE DERIVATIVES AS ALPHA-1A ADRENOCEPTOR LIGANDS | GLAXO GROUP LIMITED (GB) | 2000-11-09 | — | — | WO | disclosed |