Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 2/20 | 0.47 |
| ▸ | MAP2K1 | Q02750 | 13/20 | 0.44 |
| ▸ | RAF1 | P04049 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6431158 | 0.87 | TSHR (0.47) | MAP2K1MAPK1EPHX2EGFRALDH1A1 | |
| SCHEMBL6431219 | 0.81 | ALDH1A1 (0.50) | MAPK1ALDH1A1HSD17B10 | |
| SCHEMBL6430655 | 0.79 | ALDH1A1 (0.48) | MAPK1ALDH1A1HSD17B10 | |
| SCHEMBL1890082 | 0.77 | ALDH1A1 (0.60) | IDH1MAPK1ALDH1A1HSD17B10 | |
| SCHEMBL6431150 | 0.77 | ALDH1A1 (0.51) | IDH1MAPK1ALDH1A1HSD17B10 | |
| SCHEMBL6431609 | 0.72 | HRH3 (0.52) | MAP2K1MAPK1ALDH1A1HSD17B10 | |
| SCHEMBL29531493 | 0.72 | KDM4E (0.64) | MAPK1ALDH1A1 | |
| SCHEMBL8796387 | 0.72 | KDM4E (0.64) | MAPK1ALDH1A1 | |
| SCHEMBL16619546 | 0.69 | ALDH1A1 (0.46) | MAPK1ALDH1A1HSD17B10 | |
| SCHEMBL31125082 | 0.69 | EPHX2 (0.51) | IDH1MAP2K1RAF1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0929526-B1 | QINOLINE DERIVATIVES INHIBITING THE EFFECT OF GROWTH FACTORS SUCH AS VEGF | ASTRAZENECA AB (SE) | 2005-07-27 | — | — | EP | disclosed |
| US-6809097-B1 | ANTIANGIOGENIC AND/OR VASCULAR PERMEABILITY | ZENECA LIMITED (GB) | 2004-10-26 | — | — | US | disclosed |
| EP-0929526-A1 | QINOLINE DERIVATIVES INHIBITING THE EFFECT OF GROWTH FACTORS SUCH AS VEGF | ZENECA LIMITED (GB) | 1999-07-21 | — | — | EP | disclosed |
| WO-1998013350-A1 | QINOLINE DERIVATIVES INHIBITING THE EFFECT OF GROWTH FACTORS SUCH AS VEGF | ZENECA LIMITED (GB) | 1998-04-02 | — | — | WO | disclosed |