Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | EHMT2 | Q96KQ7 | 2/20 | 0.48 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 3/20 | 0.45 |
| ▸ | ACHE | P22303 | 3/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | HIF1AN | Q9NWT6 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6431158 | 0.92 | TSHR (0.47) | ALDH1A1HSD17B10MAPK1CASP1CASP7 | |
| SCHEMBL5649656 | 0.83 | ALDH1A1 (0.56) | ALDH1A1HSD17B10MAPK1CASP1CASP7 | |
| SCHEMBL374339 | 0.81 | ALDH1A1 (0.67) | ALDH1A1HSD17B10MAPK1CASP1CASP7 | |
| SCHEMBL6434987 | 0.79 | IDH1 (0.47) | ALDH1A1HSD17B10MAPK1 | |
| SCHEMBL6433972 | 0.77 | ALDH1A1 (0.54) | ALDH1A1HSD17B10MAPK1CASP1CASP7 | |
| SCHEMBL25616178 | 0.76 | EHMT2 (0.66) | ALDH1A1EHMT2EHMT1BCHEACHE | |
| SCHEMBL20032548 | 0.74 | ALDH1A1 (0.64) | ALDH1A1HSD17B10MAPK1CASP1CASP7 | |
| SCHEMBL19476848 | 0.73 | EHMT2 (0.55) | EHMT2EHMT1BCHEACHEMCHR1 | |
| SCHEMBL25260320 | 0.73 | ALDH1A1 (0.54) | ALDH1A1HSD17B10MAPK1CASP1CASP7 | |
| SCHEMBL2176399 | 0.73 | ALDH1A1 (0.62) | ALDH1A1HSD17B10MAPK1CASP1CASP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0929526-B1 | QINOLINE DERIVATIVES INHIBITING THE EFFECT OF GROWTH FACTORS SUCH AS VEGF | ASTRAZENECA AB (SE) | 2005-07-27 | — | — | EP | disclosed |
| US-6809097-B1 | ANTIANGIOGENIC AND/OR VASCULAR PERMEABILITY | ZENECA LIMITED (GB) | 2004-10-26 | — | — | US | disclosed |
| EP-0929526-A1 | QINOLINE DERIVATIVES INHIBITING THE EFFECT OF GROWTH FACTORS SUCH AS VEGF | ZENECA LIMITED (GB) | 1999-07-21 | — | — | EP | disclosed |
| WO-1998013350-A1 | QINOLINE DERIVATIVES INHIBITING THE EFFECT OF GROWTH FACTORS SUCH AS VEGF | ZENECA LIMITED (GB) | 1998-04-02 | — | — | WO | disclosed |